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Step 1 stuff > Teratogens, torches > Flashcards

Teratogens, torches Flashcards

1
Q

ACE inhibitors

A

renal damage

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2
Q

Alcohol

A

FAS (birth defects, mental retardation)

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3
Q

Alkylating agents (2)

A

Absence of digits

multiple anomalies

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4
Q

Aminoglycosides

A

CN VIII toxicity

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5
Q

Cocaine (3)

A

Abnormal fetal development
fetal addiction
placental abruption

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6
Q

Diethylstilbestrol (DES)

A

Vaginal clear cell adenocarcinoma

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7
Q

Folate antagonists

A

Neural tube defects

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8
Q

Iodide (lack or excess) (2)

A

goiter

hypothyroidism

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9
Q

Lithium

A

Ebstein’s anomaly (atrialized RV)

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10
Q

Maternal diabetes

A

Caudal regression syndrome (anal atresia to sirenomelia)

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11
Q

Smoking (4)

A

Preterm labor
Placental problems
IUGR
ADHD

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12
Q

Tetracyclines

A

Discolored teeth

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13
Q

Thalidomide

A

flipper limbs

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14
Q

Valproate, carbamazepine

A

Inhibition of intestinal folate absorption: take 10x normal dose

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15
Q

Warfarin (3)

A

Bone deformities
fetal hemorrhage
abortion

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16
Q

X-rays, anticonvulsants

A

Multiple anomalies

17
Q

Toxoplasma gondii: transmission

A

cat feces, undercooked meat

18
Q

Toxoplasma gondii: mom

A

Asymptomatic, rarely lymphadenopathy

19
Q

Toxoplasma gondii: neonate (3)

A

Chorioretinitis
Hydrocephalus
Intracranial calcifications

20
Q

Rubella: transmission

A

respiratory droplets

21
Q

Rubella: mom (3)

A

Rash
Lymphadenopathy
Arthritis

22
Q

Rubella: neonate (3)

A

PDA (or pulm artery hypoplasia)
Cattaracts
Deafness (w/w/o blueberry muffin rash)

23
Q

CMV: transmission

A

sex, organ transplants

24
Q

CMV: mom

A

Usually asymptomatic, maybe mono-like

25
Q

CMV: neonate (2)

A 
Hearing loss (unilateral)
Seizures
26
Q

HIV: mom

A

Variable, depends on CD4 count

27
Q

HIV: neonate (2)

A

Recurrent infections

Diarrhea

28
Q

HSV: transmission

A

skin or mucous membrane contact

29
Q

HSV: mom

A

Usually asymptomatic, maybe herpetic vesicular lesions

30
Q

HSV: neonate (2)

A

Encephalitis

Herpetic (vesicular) lesion

31
Q

Syphilis: mom (3)

A

Chancre
Disseminated rash
Cardiac/neurological disease

32
Q

Syphilis: neonate (4)

A

stillbirth common
hydrops fetalis
facial abnormalities (notched teeth, saddle nose, short maxilla)
saber shins

Step 1 stuff (36 decks)

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