Toxicology

Question 1

Toxicokinetics

Answer 1

The disposition of poisons in the body

Large Vd = hard to remove

Question 2

Toxicodynamics

Answer 2

Harmful effects of toxins

Question 3

Occupational toxicolgy

Answer 3

Usually inhalation or skin contact

Benzene, carbon tetrachloride, chloroform, toluene

Question 4

Environmental toxicology

Answer 4

Substances in food air water soil

Ecotoxicology: effects of physical and chemical agents on a defined ecosystem

Question 5

Toxicological Dose-Response Curve

Answer 5

No observed adverse effect level
Low observed adverse effect level
Lethal dose 50

Question 6

Carbon monoxide

Answer 6

Odorless, competes with oxygen for Hb
25ppm for an 8hr workday

Headache, progress to death

Question 7

Sulfur dioxide

Answer 7

Combustion of fossil fuels
Forms acid on contact with mucous membranes

Bronchial irritation and spasm, pulmonary edema

Question 8

Nitrogen dioxides

Answer 8

Brownish irritant gas from fires and silage

Deep lung irritation, pulmonary edema, irritation, death at high conc

Question 9

Ozone

Answer 9

Bluish irritant gas

Irritation and dryness of mucous membranes

Question 10

Aliphatic and halogenated hydrocarbons

Answer 10

Aspiration with chemical pneumonitis and pulmonary edema

Question 11

Aromatic hydrocarbons

Answer 11

Industrial solvents and gasoline

CNS depressant, carcinogen

Question 12

Asbestos

Answer 12

Fibers, lipophilic, poorly metabolized

Lung disease