Regulation of Gene Expression Flashcards
Levels of control
transcriptional, RNA processing, RNA transport and localization, mRNA degradation, translational, protein activity control
Promotor
RNA Pol II and TF bind to DNA upstream
Enhancer
DNA where regulatory proteins increase expression
Silencer
DNA locus where regulatory proteins decrease expression
DNA methylation
mutes DNA
histone methylation
transcriptional repression
histone acetylation
relaz DNA coiling, more transcription
histone deacetylation
tightens DNA coiling
Prokaryotic control
Positive and negative control (lactose)
negative for Trp
Eukaryotic Gene Regulation
Coordinate regulation:
Hormone response system (intracellular or cell surface)
Regulation through DNA
access, amount, arrangement of DNA
mobile DNA elements