Cancer Treatment

Question 1

Chemotherapy to kill dividing cells

Answer 1

1. Antimetabolites
2. Alkylating agents chemically crosslink DNA
3. Antitumor antibiotics
4. Plant derived to inhibit topoisomerase or mitotic spindle

Question 2

nF-kB

Answer 2

Family of five transcription factors that are constitutively active in many cancers

Could try to suppress it

Question 3

Small Molecules in Ras Map

Answer 3

Drugs target RTK inhibitors, B-raf inhibitors, Raf inhibitors, Mak inhibitors

Question 4

Multidrug resistance proteins

Answer 4

ABC transporters pump hydrophobic drugs out of the cell

Question 5

Monoclonal antibodies (MAb)

Answer 5

Purified antibodies for specific for molecules such as cancer cells

Cancer cells injected in a rat, their antibodies are collected (hybridomas), MAbs isolated and humanized

Question 6

Imatinib (Gleevec)

Answer 6

Blocks Bcr-Abl protein to inhibit tyrosine kinases

Question 7

PD1 inhibitors

Answer 7

Tumors can protect themselves from immune system by expressing receptors to bind inhibitory receptors on T cells (such as PD1)

A PD1 inhibitor blocks the protein so the immune system can attack the cancer