Genetics Of Cancer

Question 1

Cancer development

Answer 1

Initiating mutation, acquisition of genomic instability, cancer hallmarks, genetic evolution

Question 2

Two hit model of carcinogenesis

Answer 2

Inherited: first mutation already present in germ line, then a somatic mutation at some point

Sporadic: first hit occurs in embryo, then another in somatic

Question 3

Tumor supressor genes

Answer 3

Recessive mutation, loss of function
Germline mutation (inherited)

Question 4

Oncogenes

Answer 4

Dominant mutation, gain of function, not inherited

Question 5

Protooncogenes

Answer 5

Encode transcription factors that regulate cell growth

Mutation leads to oncogene - gain of function