Homocysteine Metabolism Flashcards

1
Q

Methionine Synthase

A

Uses N5methylTHF and B12 to turn homocysteine into methionine (regenerates, not synthesized)

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2
Q

SAM

A

Created from methionine, used to donate methyl groups and build nucleotides

Activates cystathione beta synthase (break down HCY)
Inhibit MTHFR and BHMT (prevent HCY to be made into methionine)

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3
Q

Hyperhomocysteinemia

A

Problem with MTHFR

Atherosclerosis, stroke, etc

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