Cell Receptors

Question 1

Ion channel receptors

Answer 1

ACh

Question 2

Tyrosine Kinase

Answer 2

Ras-MAP (growth factor): Grb2, SOS, Ras, Raf

Akt (insulin): IRS, Grb2m PIP, PI3 kinase

Question 3

JAKSTAT

Answer 3

(cytokines): Jak, Stat

Question 4

serine threonine

Answer 4

(TGF beta): type II receptor, type I receptor, R-Smad, Co smad

Question 5

GPCR

Answer 5

Hetertrimeric: alpha, beta and gamma, adenylyl cyclase, cAMP, cAMP phosphodiesterase

alpha s: stimulates adenylyl cyclase
alpha i: inhibits
alpha q: activates phopholipase c

Question 6

Guanylyl cyclase

Answer 6

membrane bound: cGMP and protein kinase G
inreacellular: NO

angina, heart failure, erectile dysfunction

Question 7

Myasthenia Gravis

Answer 7

patient develops antibodies against Ach receptors, decreased signal transmission

muslce weakness, difficulty chewing/swallowing, double vision

Question 8

Cholera

Answer 8

toxin targets Gs, cannot hydrolyze, will always be active, increase cAMP, death by dehydration

Question 9

Whooping cough

Answer 9

targets Gi, cannot inhibit adenylyl cyclase, increase cAMP, accumulation of fluid in lungs