Enzyme Regulation Flashcards

1
Q

Allosteric Regulation

A

modified by noncovalent binding of an effector at a site other than active site, causes confromation changes

positive or negative, homo or heterotropic

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2
Q

Covalent modifications

A

phosphorylation, acetylation, ubiquitination

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3
Q

mechanisms of regulation

A

substrate availability, product inhibition, allosteric, covalent, synthesis or degradation of enzyme

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4
Q

PFK1 and PFBase1 regulation by F26BP

A

low glucose activates FBPase2, decreases F26BP, activates FBPase1 = gluconeogenesis

high glucose activates PFK2, increases F26BP, activates PFK1, = glycolysis

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5
Q

Zymogens in digestion

A

trypsinogen and chymotrypsinogen must be activated by peptidases

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