Metabolism And Cancer

Question 1

Warburg Effect

Answer 1

Reprogrammed metabolic pathway in cancer cells

Cancer cells take up more glucose and produce more lactate, regardless of oxygen

Leads to more glucose uptake

Question 2

P53 as a tumor suppressor

Answer 2

Decreases transcription of GLUT 1,4,3
Reduces hexokinase
Inhibits G6PD
Blocks angiogenesis

Trying to shut down glycolysis

Question 3

HIF1

Answer 3

A transcription factor that shifts metabolism in hypoxic conditions (center of tumor) by increasing glycolysis and decreasing mitochondrial functions

In hypoxic conditions, HIF1 inhibits alpha KGDG, so increases citrate for fatty acid synthesis (reverse flux of TCA)

Question 4

IDH and 2HG

Answer 4

D2HG is a gain of function mutation in gliomas and AML