Pharmacodynamics Flashcards
1
Q
Pharmacodynamics
A
What the drug does to the body
2
Q
Quantal dose response curve
A
ED50, threshold dose (steep curve, little variability)
Magnitude of response is graded so more dose means more effect
3
Q
Agonist vs antagonist
A
Agonist: drug that binds receptors to elicit a response
Antagonist: bind receptors but do not elicit response
4
Q
Drug development process
A
Discovery and characterization of drug Preclinical trials (acute subacute and chronic toxicity must be tested on 2 animas, pharmacological profile, carcinogenesis,etct) IND application Clinical studies Submission of NDA Approval of NDA Postmarketing surveillance
