Topic 7.3 Flashcards

1
Q

Which trace element is necessary for normal thyroid hormone synthesis?

A

Iodine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the functional unit of the thyroid gland?

A

Thyroid follicle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What fills the follicular lumen?

A

Colloid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is colloid made of?

A

thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What cells can we find scattered in the thyroid gland?

A

parafollicular, C cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do C cells secrete?

A

Calcitonin (peptide hormone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Where does the start of thyroid hormone synthesis happen?

A

extracellularly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

3 types of iodo-thyronines

A
  • T4, thyroxine, 3,5,3’,5’-tetra-iodothyronine
  • T3, 3,5,3’-tri-iodothyronine
  • Reverse T3, 3,3’,3’-tri-iodothyronine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

3 transporters useful for iodine transportation

A
  • Na/I transporters (NIS)
  • Na+,K+, ATPase
  • Pendrin : I/Cl
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What molecule stimulates expression of the NIS?

A

TSH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does thyroid peroxidase catalyze? (3)

A
  • iodide oxydation
  • thyroglobulin iodination
  • iodothyronine coupling
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Where is thyroid peroxidase located?

A

in the apical membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is T3 a coupling of?

A

DIT + MIT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is T4 a coupling of?

A

DIT + DIT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

First step of synthesis of iodothyronines

A

Iodide is oxidized and incorporated into tyrosine residues w/in thyroglobulin in the lumen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the electron acceptor of the follicular membrane?

A

H202

17
Q

When is thyroglobulin degraded?

A

Once endocytotic vesicle fuses with lysosome, then there’s proteolysis

18
Q

Which enzyme catalyzes deioniodination of MIT and DIT?

A

iodo-tyrosine deiodinase

19
Q

What is peripheral conversion?

A

T4 is converted into active T3

20
Q

Which enzymes catalyze peripheral conversion?

A

tyrosine-specific deiodinases

21
Q

Where can we find Type 1 deiodinase? (3)

A
  • Liver
  • Kidneys
  • Thyroid gland
22
Q

Where can we find Type 2 deiodinase?

A

glial cells of the CNS

23
Q

Roles of type 2 deiodinase (2)

A
  • Maintains intracellular T3

- mediates T4 to feedback on secretion of TSH

24
Q

What receptors do thyroid hormones use to act?

A

Nuclear receptors

25
Q

Structure of nuclear receptor (3)

A
  • Variable region
  • DNA binding domain
  • Hormone binding domain
26
Q

What happens to T4 once it enters its target cell?

A

Most of it is converted to T3 by 5’/3’-monodeiodinase

27
Q

Where do tyrosine receptors bind on DNA?

A

thyroid response elements (TRE) in the promoter region

28
Q

How much of the tyrosine bound to receptor is T3?

A

90%

29
Q

6 effects of thyroid hormones

A
  • increased BMR
  • increased thermogenesis
  • decreased plasma [glycerol] and [cholesterol] but increased plasma [FA]
  • Increase gluconeogenesis and glycogenolysis
  • Growth
  • increased cardiovascular effects
30
Q

What is TRH?

A

thyrotropin releasing hormonone

31
Q

What does TRH bind to?

A

Gq coupled receptor on the thyrotrophic membrane

32
Q

What does TSH bind to?

A

Gs coupled receptors on the thyroid follicular cells

33
Q

What inhibits TSH release? (2)

A
  • SST

- Dopamine

34
Q

What is hypothyroidism often due to

A

Autoimmunity : hashimoto’s disease

35
Q

What is Grave’s disease?

A

Autoimune disease in which thyroid stimulating immunoglobulins form against the TSH receptor in the thyroid gland : continual activation