Topic 7.3 Flashcards
Which trace element is necessary for normal thyroid hormone synthesis?
Iodine
What is the functional unit of the thyroid gland?
Thyroid follicle
What fills the follicular lumen?
Colloid
What is colloid made of?
thyroglobulin
What cells can we find scattered in the thyroid gland?
parafollicular, C cells
What do C cells secrete?
Calcitonin (peptide hormone)
Where does the start of thyroid hormone synthesis happen?
extracellularly
3 types of iodo-thyronines
- T4, thyroxine, 3,5,3’,5’-tetra-iodothyronine
- T3, 3,5,3’-tri-iodothyronine
- Reverse T3, 3,3’,3’-tri-iodothyronine
3 transporters useful for iodine transportation
- Na/I transporters (NIS)
- Na+,K+, ATPase
- Pendrin : I/Cl
What molecule stimulates expression of the NIS?
TSH
What does thyroid peroxidase catalyze? (3)
- iodide oxydation
- thyroglobulin iodination
- iodothyronine coupling
Where is thyroid peroxidase located?
in the apical membrane
What is T3 a coupling of?
DIT + MIT
What is T4 a coupling of?
DIT + DIT
First step of synthesis of iodothyronines
Iodide is oxidized and incorporated into tyrosine residues w/in thyroglobulin in the lumen