Topic 2 The Respiratory Effect: Haldane Effect

Question 1

• Describes how deoxygenation of blood increases its ability to carry CO2
• When increase in CO2 pressure = increased CO2 blood concentration
• When hemoglobin saturated with oxygen, its capability to hold CO2 is reduced
• Pick up CO2 in tissues where its generated and get rid of it in the lungs and exchange for O2
• Hemoglobin without oxygen acts as blood buffer by accepting H+ -> this reduced hemoglobin has higher capacity to form carbaminohemoglobin, rather than the oxygen carrying kind

Answer 1

Haldane Effect

Question 2

• CO2 + H2O H2CO3 H+ + HCO3
• H+ + HbO2 H+Hb + O2
• CO2 + HbO2 HbCOO- + H+ + O2
• In summary, Haldane relates how O2 is affecting hemoglobin’s affinity for CO2 and H+ which work to facilitate liberation of O2 and uptake of CO2 and H+

Answer 2

Bohr and Haldane are both results of