Topic 10 Immune System: Paracrine System

Question 1

• In addition to neuronal and hormonal (endocrine) communication, there is a paracrine system, which consists of local mediators that function in the immediate area around the cell from which they were released. These mediators can be proteins, amino acid derivatives, or fatty acids

Answer 1

Note

Question 2

• Locally acting autocrine/paracrine lipid messenger molecule that has physiological effects such as:
  a. Contraction and relaxation of smooth muscle
  b. Platelet Aggregation
  c. Inflammation
  d. Fever
  e. Pain Sensation
• Other local mediators include growth factors and lymphokines, which are a subset of cytokines produced by T cells
• Aspirin inhibits prostaglandin synthesis, and is thus considered anti-inflammatory and decreases blood clotting

Answer 2

1. Prostaglandins