TLRs Flashcards
1
Q
TLRs do what?
A
once activated, they activate transcription factors (notably NF-kB) that stimulate expression of genes encoding
cytokines
enzymes
other antimicrobial proteins
2
Q
what transcription factor is notably transcribed in response to TLR signaling?
A
NF-kB
3
Q
TLR –> X —> X —> X
A
TLE –> NF-kB –> interferon regulatory factors –> type 1 interferon
4
Q
cell surface TLRs include
A
TLR 1, 2, 4, 5, 6
5
Q
endosome TLRs include
A
TLR 3, 7, 8, 9
6
Q
bacterial lipopeptides are recognized by TLR
A
1, 2, 6
7
Q
bacterial peptidoglycan is recognized by TLR
A
2
8
Q
LPS is recognized by
A
TLR-4
note: LPS is an endotoxin
9
Q
TLR 3 recognizes
A
dsRNA (viral)
10
Q
TLR 7 recognizes
A
ssRNA
11
Q
TLR 8 recognizes
A
ss RNA
12
Q
TLR 9 recognizes
A
CpG DNA
