LTH II the Spleen

Question 1

Location of the spleen, role in classification

Answer 1

Left superior quadrant, no lobules

Question 2

Functions

Answer 2

1. macrophages present to destroy old RBCs
2. traps antigens
3. reservoir for 1/3 of platelets
4. hematopoiesis occurs here

Question 3

General organization

1. lobules?
2. divisions?
3. capsule composition?
4. cortext/medulla/germinal centers

Answer 3

1. no lobules
2. trabeculae divide spleen into incomplete departments
3. capsule is made from connective tissues
   i. smooth muscle
   ii. elastic fibers
   iii. collagen
4. no cortex or medulla

Question 4

General organization: parenchyma and cell groups

Answer 4

parenchyma = reticular fibers that support white and red pulp (two main components)

white pulp: rich in lymphoid tissue
red pulp: rich in red blood cells

Question 5

White pulp general organization

Answer 5

Germinal center
corona (B cells, APCs)
central artery (T cells surrounding periarteriolar lymphoid sheath
periarteriolar lymphoid sheaths (T cell sheath)

Question 6

Red pulp organization

Answer 6

1. splenic cords
2. splenic sinusoids
3. red blood cells
4. macrophage sheathed capillaries
5. pennicillar arteries

Question 7

Splenic cords are what color stained?

Answer 7

pinkish

Question 8

Splenic sinusoids stain what color?

Answer 8

they dont

Question 9

What are PALS? what are PWP?

Answer 9

PALs = periarterial lymphocyte sheath (consists of T cells and surrounds central splenic artery)

PWPs = peripheral white pulp (consists of B cells and surrounds the radial arteries leading to the marginal sinuses)

Question 10

Penicillar arterioles go where, and do what, and are surrounded by what

Answer 10

they branch out of the central artery and ramify through red pulp. they’re surrounded by macrophage sheaths that remove particles and used RBCs. they lead to splenic sinusoids.