Innate immunity activation pt II (second part of lecture)

Question 1

Complement System contains how many proteins

Answer 1

around 30 proteins

Question 2

what pathways are there

Answer 2

classical, alt, and lectin

Question 3

what do all three have in common?

Answer 3

all PWs lead to C3b formation and MAC formation

Question 4

what does C3b activate?

Answer 4

C5 component

Question 5

how many IgGs are req. to initiate the classical pw?

Answer 5

2

Question 6

how many IgM are reg. to initiate the classical pw?

Answer 6

1

Question 7

C3 convertase formation in classical activation

Answer 7

C1 binds to Abs
C1 cleaves C2 and C4
C4 binds to microbe
C2a binds to C4a

Question 8

what are the basic components of C3 convertase in classical PW

Answer 8

C2a and C4b

Question 9

Formation of C5 convertase

Answer 9

C3 convertase cleaves C3 into C3a and C3b

C3b binds to C2aC4b to become C2aC4bC3b

Question 10

C3b does what?

Answer 10

it can serve as an opsonin for phagocytosis

Question 11

what does C5 convertase do?

Answer 11

it cleaves C5 into C5a and C5b:

C5a serves as an anaphalaxion and C5b can initiate the MAC formation

Question 12

what are the 3 jobs of classical complement?

Answer 12

1) formation of MAC
2) opsonization/phagocytosis via C3b/C3bi
3) anaphalaxion via C3a/C4a/C5a

Question 13

Acute phase proteins (APP) production is regulated by

Answer 13

IL-6

Question 14

What does APP accompany?

Answer 14

inflammation

Question 15

what are APP produced by?

Answer 15

hepatocytes

Question 16

what do C reactive and mannose binding proteins do?

Answer 16

they are acute phase proteins that fix complement and opsonize

Question 17

why are PRRs emphasized in the innate system study?

Answer 17

they link innate to adaptive
they cause activation professional APCs, which activate naive T cells and secrete cytokines that stimulate T cell maturation