Monocytes/Macrophages

Question 1

Mononuclear Phagocyte System is composed of

Answer 1

circulating monocytes and differentiated tissue macrophages

Question 2

where do monocytes differentiate/mature into resident macrophages?

Answer 2

in the tissue

Question 3

what drives mono/macrophage lineages in the bone marrow?

Answer 3

monocyte/macrophage colony stimulating factor

Question 4

Functions of Macrophages

Activation

Answer 4

they sythensize TNF-alpha, IL-1, IL-6

Question 5

Functions of Macrophages

Chemotaxis/Tissue inflammation

Answer 5

IL-8 for neutrophil recruitment

IL-1 and TNF-alpha for inflammation

Question 6

Functions of Macrophages

Phagocytosis/Scavenger

Answer 6

eat, destroy, tissue repair

release fibrinogenic stim-factor and angiogenic factors

Question 7

Functions of Macrophages

Immunomodulation

Answer 7

they secrete IL-12 to compel NK and T lymphocytes to secrete IFN-gamma and IL-10 to suppress it

Question 8

Functions of Macrophages

APC

Answer 8

they present Ags to T cells at sites of infection. leads t cells to be activated.