Local versus Systemic Cytokine Effects Flashcards
1
Q
Systemic effects are brought on by
A
TNF-alpha
2
Q
Local effects are brought on by
A
IL-6
3
Q
Systemic effects include
A
fever, shock, mobilization of metabolites
4
Q
Local effects include
A
fever
acute phase protein production by hepatocytes
5
Q
TNF-alpha does what
A
increases vascular permeability:
- -> increased IgG entry,
- –> complement and cells to tissues
- -> increased fluid drainage to lymph nodes
6
Q
IL-6 does what
A
lymphocyte activation and increased antibody production
7
Q
IL-1beta does what
A
1) activates vascular endothelium
2) activates lymphocytes
3) local tissue destruction
4) increases access to effector cells
5) fever
6) production of IL-6
8
Q
IL-8 does what
A
chemotactic factor, recruits neutrophils, basophils, T cells to site of infection
9
Q
IL-12
A
activates NK cells
induces differentiation of CD4 T cells into TH1 cells
