NK cells

Question 1

NKs need what kind of prior stimulation

Answer 1

they dont

Question 2

what lineage?

Answer 2

lymphocyte

Question 3

what kind of immunity?

Answer 3

innate

Question 4

what do NKs target?

Answer 4

viral, cancerous, transplant cells

Question 5

cytotoxin mechanism

Answer 5

perforin

Question 6

Ag receptor?

Answer 6

none.

Question 7

NK cells are ___ ____ that appear to function in _____ _____

Answer 7

granular lymphocytes

immune surveillance

Question 8

immune surveillance does what

Answer 8

purges precancerous cells

Question 9

what lineage are they?

Answer 9

they arise from bone marrow but are distinct from T and B cell lineages

Question 10

Where do NK cells undergo differentiation?

Answer 10

in the bone marrow

Question 11

How does immunologic insult induce them?

Answer 11

it DOESNT

Question 12

What cytokines increase their activity?

Answer 12

IL-15 and IL-2

Question 13

what rxn are they the “major lymphocyte” of?

Answer 13

Ab-dependent cellular cytotoxicity

have membrane receptors for the Fc portion of IgG

Question 14

what kind of specificity do they have?

Answer 14

none.

Question 15

ADCC

Answer 15

Ab-dependent cellular cytotoxicity

Question 16

what Ab do they recognize?

Answer 16

IgG, the Fc portion

Question 17

what roles do ADCC play?

Answer 17

anti-viral, anti-tumor, anti-graft immunity

Question 18

What cells play a role in ADCC?

Answer 18

NKs, macs, and neutrophils

Question 19

which cells recognize IgG’s Fc portion?

Answer 19

NK, Macs, Neutrophils

Question 20

How do they kill?

Answer 20

they release porforin that creates holes in the protective coats of virally/tumorous/non-self cells

Question 21

How do they avoid hurting themselves with porforin?

Answer 21

they have a protein called protectin which binds the porforin and prevents it from causing self harm

Question 22

are NK cells MHC restricted?

Answer 22

no. they do not need MHC molecules to recognize bad cells.