Components of the Innate immune system

Question 1

Circulating effector cells (3)

Answer 1

Neutrophils, macs, NK cells

Question 2

Neutrophils

Answer 2

Early phagocytes that can kill using phagocyte oxidase, iNOS, and lysosomal vesicles

can form NETS to capture microbes

live 2-3 day

produce inflammatory mediators such as cytokines, prostaglandins, leukotrienes

cytoplasmic granules:

peroxidase, lysozyme, defensins, degradative enzymes

60-70% of the white blood cells in circulation

Question 3

Macrophages can do what

Answer 3

phagocytize, cytokine induced inflammation

Question 4

NK cells

Answer 4

kill directly through granulocytes that lyse, and macrophage activation

Question 5

Circulating effector proteins (3)

Answer 5

complement proteins, mannose binding lectin (collectin), C-reactive protein

Question 6

complement proteins

Answer 6

opsonize for phagocytosis, leukocyte activation, directly killing

Question 7

mannose binding lectin (collectins)

Answer 7

the receptor of the lectin pathway, opsonizes and activates complement

Question 8

C-reactive protein

Answer 8

opsonizes, complement activation

Question 9

TNF, IL-1, chemokines

Answer 9

inflammation

Question 10

IFN-alpha/beta

Answer 10

resistance to viral infection

Question 11

IL-12

Answer 11

INF-gamma production by NK cells and T cells

Question 12

IL-15

Answer 12

proliferation of NK cells

Question 13

IL-10, TGF-beta

Answer 13

control of inflammation