Abs

Question 1

the light chains have two types

Answer 1

lambda and kappa

Question 2

the heavy chains have 5 kinds

Answer 2

delta, epsilon, mu, alpha, gamma

Question 3

the constant region of the heavy chain is called the

Answer 3

Fc region

Question 4

the effector properties of Abs comes from the

Answer 4

Fc region: the constant region

Question 5

which part of the Ab is responsible for Ag recognition an which part is responsible for the effector properties

Answer 5

the variable region - Ag rec

the Fc region (constant) - effector properties

Question 6

Fab and F(ab’)

Answer 6

when Ab is degraded by papain, it produces two fragments, each containing a binding site: Fab and Fc.

when Ab is degraded by pepsin, it produces only one fragment which possesses two Ag binding sites F(ab’)

Question 7

Papain creates

Answer 7

two fab fragments each with a binding site and the Fc fragment

4 fragments all together

Question 8

Pepsin creates

Answer 8

one fragment with two binding sites (F(ab’))

Question 9

what part of the Ab classifies it?

Answer 9

the heavy chain constant region

Question 10

IgG has how many subclasses?

Answer 10

four (IgG1-4)

Question 11

IgA has how many subclasses?

Answer 11

2 (IgA1-2)

Question 12

Ig class functions: IgA

Answer 12

mucosal immunity

neonatal passive immunity

Question 13

Ig class functions: IgD

Answer 13

Naive B cell antigen receptor

Question 14

Ig class functions: IgE

Answer 14

Mast cell activation, immediate hypersensitivity

Question 15

Ig class functions: IgG

Answer 15

opsonization, complement activation, antibody dependency cell cytotoxicity (NK cells!), neonatal immunity, feedback inhibition of B cells

Question 16

IgM

Answer 16

Pentamer

naive B cell antigen receptor, complement activation

Question 17

Abs have at least 6 functions.

Answer 17

1) neutralization
2) opsonization
3) ADCC activation
4) Agglutination
5) Degranulation
6) complement activation

Question 18

Agglutination

Answer 18

Abs have at least 2 Ag binding sites: they can trap multiple pathogens into a mesh work called an immune complex

Question 19

Opsonization

Answer 19

Fc regions can activate neutrophils and MOs that enhance their phagocytosis

Question 20

Degranulation

Answer 20

cause degranulation of mast cells, basophils, eosinophils

via IgE binding to the Fc receptors

Question 21

IgA morphology

Answer 21

homodimer

has a J chain and a secretory component

Question 22

Direct biological activity of Ab are attributable to

Answer 22

the heavy chain Fc region

Question 23

What region of the Ab confers its function?

Answer 23

the constant heavy chains

Question 24

Neonatal passive immunity is conferred by

Answer 24

IgA

Question 25

Neonatal immunity is conferred by

Answer 25

IgG

Question 26

Which is the naive B cell receptor?

Answer 26

IgD

Question 27

Which confers immediate hypersensitivity?

Answer 27

IgE

Question 28

Which confers mucosal immunity?

Answer 28

IgA

Question 29

Which is involved in B cell feedback inhibition?

Answer 29

IgG

Question 30

Which is a naive B cell receptor and also a complement activation?

Answer 30

IGm