NOD like receptors Flashcards
1
Q
what are NLRs
A
NOD like receptors are a cytosolic receptor that recognize DAMPs and PAMPs in the cytosol
2
Q
what is the “NLR”
A
a structural domain shared by all the receptors
“nucleotide oligomerization domain”
3
Q
NLRP 3 –>
A
NLRP -3 + adaptor proteins + caspase-1 (inactive) –> NLRP-3 inflammasome –> caspase-1 active –> Pro-IL 1beta cleaved to IL-1 beta —> IL-1beta secreted –> acute inflammation
4
Q
autoinflammatory functions
A
gain of function mutation in NLRP-3
5
Q
gout
A
join disease caused by deposition of urate crystals, recognized by NLRP-3 and inflammasome mediated inflammation
6
Q
NOD-2
A
NLR specific for bacterial peptides that have entered the cytosol
7
Q
NOD-2 activates
A
NF-kB transcription factor
8
Q
inflammatory bowel disease
A
associated with polymorphisms of nod-2
