Thrombosis and Clotting Flashcards
What type of cells line the small artery
Endothelial cells
What do the endothelial cells make
The basal lamina
What surrounds the basal lamina
Smooth muscle cells
What structure surrounds the smooth muscle cells
Interstitial collagen fibres
What does the lumen of the artery contains
RBCs
WBCs
Platelets
Plasma
Platelets are ____ normally exposed to the interstitial collagen fibres
NOT
What does plasma consist of
Water and numerous proteins and molecules
Plasma is_____
Blood without RBCs, WBCs and platelets and contains clotting factors
Serum is_____
Plasma without clotting factors
Where are clotting factors made
Liver or by endothelial cells
What are clotting factors
An amplification system resulting in thrombin production
Function of thrombin
Turn soluble fibrinogen into insoluble fibrin
Clotting Cascade
- Damage
- Tissue Factor
- Prothrombin»>Thrombin
- Thrombin turns fibronogen to Fibrin
What is meant my damage
- Exposure of interstitial collagen to plasma
2. Exposure of a molecule called Tissue Factor
Plasma clotting factors are activated when____
Interstitial collagen comes into contact with plasma
Where is Tissue Factor released from
Smooth muscle cells
What initiates the clotting cascade
Tissue factor binding to clotting factors
Many clotting factors are_____
Serine proteases
How do clotting factors activate other clotting factors
Cleave serine amino acid and produces a redundant fragment
Clotting cascade leads to the production of _____ from ______
Thrombin and Prothrombin
Function of Prothrombin
Converts fibrinogen to fibrin (insoluble)
Endpoint of clotting cascade
Production of insoluble fibrin strands that form a meshwork
Where are platelets produced
Bone marrow
What cell are platelets produced from
Megakaryocyte
