Chronic Inflammation

Question 1

Clinical presentations

Answer 1

Malaise and weight loss

Loss of fucntion

Question 2

Causes of chronic inflammation

Answer 2

inability to remove debris, ongoing acute insult or large volume of damage

Question 3

Organisation

Answer 3

outcome of acute inflammation

Question 4

Granulation tissue mechanism

Answer 4

1. Angiogenesis (capillaries grow into inflammatory mass)
2. Fibroblasts lay down collagen to repair damaged tissue
3. Collagen replaces inflammatory exudate
4. Macrophages phagocytose old tissue
5. New connective tissue replaces dead or necrotic tissue
6. Contracts and pull together

Question 5

Examples

Answer 5

Scars
Acne
Cholecystitis
Peptic ulcer
Osteomyelitis