Therapeutics

Question 1

Name some drugs that cause torsade de pointes.

Answer 1

antiarrhythmic drugs, including quinidine, procainamide, and disopyramide

antipsychotics or tricyclic antidepressants

methadone, erythromycin, and ketoconazole

Question 2

Name an antibiotic that causes torades de pointes

Answer 2

Erythromycin

Question 3

What drugs cause erythema multiforme?

Answer 3

NSAIDs.

Allopurinol (treats gout).

Certain antibiotics, such as sulfonamides and aminopenicillins.

Anti-seizure drugs

Question 4

What is an ADR?

Answer 4

– ‘A response to a drug which is noxious and unintended, and which occurs at doses normally used in man for the prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function.’

Question 5

What is the difference between SJS and TEN?

Answer 5

TEN is THE WORST

Question 6

What are type A ADR reactions vs type B?

Answer 6

Type A reactions – sometimes referred to as augmented reactions – which are ‘dose-dependent’ and predictable on the basis of the pharmacology of the drug 2. Type B reactions – bizarre reactions – which are idiosyncratic and not predictable on the basis of the pharmacology.