Fungal infections and drugs Flashcards

1
Q

What is amphotericin?

A

• Binds to ergosterol and forms pores in cell membrane

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2
Q

What is azoles?

A

• Inhibit ergosterol synthesis and damage fungal cell membrane

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3
Q

What is echinocandins?

A

Caspofungin, Anidulafungin, Micafungin
• Non-competitive inhibitors of 1,3-beta-D-glucan resulting in
reduced cell wall cross linking and weakened cell wall

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4
Q

What is Flucytosine?

A

Developed as potential tumour agent
• Interferes with DNA and protein synthesis
• Always used in combination treatment due to risk resistance

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5
Q

What is mucormycosis?

A

Caused by a variety of moulds in the order Mucorales
• Rhizopus, Mucor, Rhizomucor,
• Typically affects patients with haematological
malignancies, high dose steroids or DKA
• Devastating and aggressive rhino-orbital cerebral and
pulmonary infections

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6
Q

What are some dermatophytes?

A
Tinea pedis (athelete’s foot)
• Tinea corpis (“Ring worm”)
• Trichophyton spp
• Treat with topical terbinafine, ketoconazole,
clotrimazole
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7
Q

What is terbinafine?

A

Squalene epoxidase inhibition

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