Test 4 Drugs Flashcards
What is clopidogrel(Plavix)?what receptor does it work against?
P2Y12 antagonist
ADP receptor
What is abciximab(Reopro)? What receptor does it work against?
GP2b/3a antagonist
Fibrinogen receptor
What is enoxaparin(Lovenox)? Route and time to take it?
LMWH
SC BID
What is dalteparin(Fragmin)?
LMWH
What is Protamine sulfate? Which type of drugs can it be used on? MOA?
Heparin antidote
Used for heparin and LMWH
binds to heparin to go to kidneys and be excreted
What is warfarin(Coumadin)? Route? How many days must you discontinue it before going into surgery?
Coumarin/vitamin K antagonist
Oral
Discontinue 3-5 days before surgery
What is rivaroxaban(Xarelto)? Route? Time taken during the day?
Direct factor 10a inhibitors
Oral
Once daily
What is apixaban(Eliquis)? Route? Time taking during the day?
Direct factor 10a inhibitors
Oral
BID
What is edoxaban(Savaysa)? Route?
Direct factor 10a inhibitors
Oral
What is fondaparinux(Arixtra)? Route?
Direct factor 10a inhibitor
SC
What is dabigatran(Pradaxa)? Route? What time is it taken?
Direct thrombin inhibitor
Oral
BID
What is argatroban(Argatroban)? Route? What is it specifically used for?
Direct thrombin inhibitor
IV
HIT
What is lepirudin(Refludan)? Route?
Direct thrombin inhibitors
IV
What is praxbind(Idarucizumab)?
Antidote for direct thrombin inhibitor
What is streptokinase(Streptase)? Route?
Fibrinolytic
IV
What is urokinase(Abbokinase)? Route?
Fibrinolytic
IV
What is alteplase(Activase)? What is it also called? Route?
Fibrinolytic
rtPA
IV
What is reteplase(Retavase)? Route?
Fibrinolytics
IV
What is tenecteplase(TNKase)? Route?
Fibrinolytics
IV
What is lomitapide(Juxtapid)? Route? MOA?
MTP(microsomal triglyceride transfer protein)
Oral
Prevents assembly of chylomicrons and VLDL
What is Mipomersen(Kynamro)? Route and time? MOA?
APO B100 inhibitor
SC once/week
Inhibits APO B100 synthesis so liver can’t make VLDLs
What is alirocumab(Praluent)? Route and time? MOA?
PCSK9 inhibitors
SC once/2wks
Blocks PCSK9 which breaks down LDL receptors on the liver
What does PCSK9 do?
Breaks down LDL receptors on the liver to prevent LDL absorption into the liver
What is evalocumab(Repatha)? Route and time? MOA?
PCSK9 inhibitors
SC once/2wks
Blocks PCSK9 which breaks down LDL receptors on liver
What is rosuvastatin(Crestor)? MOA? How does it effect levels?
HMG-CoA reductase inhibitors (Statins)
Prevents cholesterol production
Decreases LDL, VLDL and TG
Increases HDL
What is atrovastatin(Lipitor)? MOA? How does it effect levels?
HMG-CoA reductase inhibitors (Statins)
Prevents cholesterol production
Decreases LDL, VLDL and TG
Increases HDL
What is simvastatin(Zocor)? MOA? How does it effect levels?
HMG-CoA reductase inhibitors (Statins)
Prevents cholesterol production
Decreases LDL, VLDL and TG
Increases HDL
What inhibits the break down of statins? How?
Grapefruit
Both compete for the same enzyme to be broken down by in the liver
What is ezetimibe(Zetia)? MOA? What is unique about the drug? How many side effects?
Cholesterol absorption inhibitors
Blocks NPC1L1 transporter which blocks the absorption of cholesterol on the brush border of Small intestine
Stays in enterohepatic circulation
Few side effects
What is cholestyramine(Questran)? MOA? Indication?
Bile acid sequestrants
Binds to bile acid to excrete bile from the body, thus causing an increase in bile production to use more cholesterol
IBS-D