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Pharmacology > Antiemetic/ Antinausea Drugs > Flashcards

Antiemetic/ Antinausea Drugs Flashcards

1
Q

What trimester is emesis common in pregnancy?

A

1st trimester

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2
Q

What conditions are associated w/ emesis(5)?

A 
Cold/flu
Pregnancy
Motion sickness
Inner ear infection
Drugs
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3
Q

What are the 2 control centers that can cause emesis? Where are they located?

A

CTZ and VC

In brainstem

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4
Q

What are the 5 neurotransmitters that causes N/V?

A 
ACh
Dopamine
Sub P
Histamine
Serotonin
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5
Q

What can cause emesis?

A

Electrolyte imbalance
Fluid imbalance
Acid/base imbalance

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6
Q

What ages need strict Tx w/ emesis? What can they cause?

A

Elderly and infants

Cause tear sutures
Increase pressure on organs

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7
Q

What is scopolamine(Transdermal-scop, scopace)? What is it used to Tx?

A

Anticholinergic drug

Tx N/V

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8
Q

What do serotonin antagonists for Tx of emesis end in?

A

-setron

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9
Q

What is granisetron(Kytril)? What is it indicated for?

A

5HT antagonist

Chemo
Radiation
PONV
pregnancy

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10
Q

What is ondansetron(Zolfran)? Indications?

A

5HT antagonist

Chemo
Radiation
PONV
pregnancy

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11
Q

What is palonosetron(Aloxi)? Indications?

A

5HT antagonist

Chemo
Radiation
PONV
pregnancy

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12
Q

What is the receptor for sub P receptor?

A

NK1 receptor

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13
Q

What is aprepitant(Emend)? Route?

A

NK1 antagonist

IV and oral

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14
Q

Where are many of the NK1 antagonist receptors?

A

VC and CTZ

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15
Q

What is prochloperazine(Compazine)?

A

Antidopaminergic

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16
Q

What is promethazine(phenergan)? Contraindication and why?

A

Antidopaminergic

<2yo because it can cause fetal respiratory depression

17
Q

What is Benadryl? Indication?

A

H-1 antagonist

Motion sickness

18
Q

Why is Dramamine? Indication?

A

H-1 antagonist

Motion sickness

19
Q

What is Antivert? Indication?

A

H-1 antagonist

Motion sickness

20
Q

What is dronabinol(Marinol)? What does it relieve?

A

CB-1 agonist

Relieves N/V

21
Q

Where are CB-1 receptors found in the body?

A

Brainstem

GI tract

22
Q

What is Emetrol? What is in it? How does it provide nausea relief?

A

Other anti nausea medication

Fructose/dextrose and phosphoric acid

Reduces SM contraction
Decreases peristalsis

Pharmacology (27 decks)

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