T9 Diseases and Syndromes Flashcards
MLF Lesion
prevents adduction of the eye (Right MLG= no right Eye adduction(left moving) )
PPRF Lesion
prevents conjugate gaze of both eyes ( Right PPRF= no conjugate to the right)
1 1/2 Syndrome
PPRF and MLF lesioned No adduction of one eye and no conjugate gaze (ex. Right eye can’t adduct (left moving) also both eyes can’t conjugate to the right
Pathological Nystagmus
Lesion of vestibular labyrinth, CNVIII, MLF or cerebellum
Kinentosis
Motion sickness
Unilateral Hearing Lose
only due to lesions at
- Ear
- CNVIII
- Cochlear Nuclei
Presbyacusis
Age related hearing loss, progressive and bilateral
Parkinsons Disease
Insufficient release of dopamine
Decrease inhibition of the GPI- increased thalamic inhibition
Symptoms: Alpha Synucleins to Lewy bodies Tremor (resting) Bradykinesia Decreased facial expression short strides
Therapy:
1st L-Dopa(up dopamine synth) and Carbidiopa (reduces L-Dopa Meta.)
MOA and COMT inhibitors
Dopamine AGONIST
Anticholinergics/ Muscarinic antagonist
Huntington Disease
Degeneration of GABAergic greater inhibition Sth reduced GPI restriction of thalamus
AD disease
Symptoms -enlarged ventricles Chorea Depression Dementia
Therapy:
Antidepressants
D2 receptor antagonist
VMAT inhibitors
Sydenham
Choretic disorder
rheumatic fever
Athetosis
Slow, involuntary writing movements
Hemiballismus
Violent flinging of limbs
contralateral Sth injury
One side of body affected
Spino-Spinocerebellum lesion
Anterior Lobe
effects posture and movement
Gait ataxia lurching to one side
ALCOHOLISM
Cerebrocerebellum lesion
Posterior Lobe
Accuracy and timing of movements deficient, poor coordination
Slurred speech ( Dysarthria)
Post Pointing ( Dysmetria)
Intention tremor
Vestibulocerebellum lesion
Flocculonodular Lobe
Equilibrium in relation to motion
Nystagmus
Titubation
Truncal ataxia
