T8 Disease Pack Flashcards
Lou Gehrig’s Disease (ALS)
-Soma Effects *Muscle Atrophy and weakness *Hyporeflexia *Fasciculations and Fibrillations
Poliomyelitis
Soma Effects *Muscle Atrophy and weakness *Hyporeflexia *Fasciculations and Fibrillations
Etiology:RNA virus, attacks ventral spinal grey matter
Guillain-Barre
Schwann Cells Demyelination
- Autoimmune Attacks
- Post infection
Diphtheria
Schwann Cells Demyelination
*Autoimmune Attacks
Botulism
Nerve ending
*Toxic anaerobic bacterial protease reduces ACH release
Alpha-Latrotoxin
Nerve ending
*Toxin from Black widow Spider causes massive ACh release affecting presynaptic exocytotic proteins
Beta-Bungarotoxin
Nerve ending
*Toxin in snake venom provokes ACh release followed by ACh depletion
Curare
Nerve ending
- Blocks nACHRs
- blow darts
Myasthenia Gravis
End Plate
*Chronic Autoimmune (antibodies to nAChRs)
*Loss of strength after repeated use,restoration of strength after rest
* Wider Synaptic cleft, Smaller Junctional Folds
*1st symptom is diplopia with gradual increase
*Waning
Therapies
Azathiopirine, Corticosteroid: Immunosuppressing meds
Pyridostigmine:AChE inhibitor
Thymectomy
nACHR defects
End Plate
Myathenisas
Synaptic Cleft *Present at birth signs shown before the age of 2 2 forms • Abnormal Ach bind • ACh challe brief opening time
Myotonias
Muscle Fiber
- Auto Dom.
- Lesion of the CL Channel
- increased excitability
Muscular dystrophy
Muscle Fiber
- X linked recessive -lack of Dystrophin protein
- progressive muscle weakness
Lambert-Eaton Syndrome
NMJ
- Autoimmune- Presynaptic voltage gated calcium channels
- Found in Pulm. Small cell Cancer
- Reduces ACh release
- Waxing Response
Therapy :
Plasma exchange
4-Aminoprydine (K channel Blocker) (prolong action potentials)
Leading Poisoning
Motor neuropathy Adults
Encephalopathy children younger than 6
Bilateral Weakness of extensor of fingers and wrist
