T8 Disease Pack Flashcards
Lou Gehrig’s Disease (ALS)
-Soma Effects *Muscle Atrophy and weakness *Hyporeflexia *Fasciculations and Fibrillations
Poliomyelitis
Soma Effects *Muscle Atrophy and weakness *Hyporeflexia *Fasciculations and Fibrillations
Etiology:RNA virus, attacks ventral spinal grey matter
Guillain-Barre
Schwann Cells Demyelination
- Autoimmune Attacks
- Post infection
Diphtheria
Schwann Cells Demyelination
*Autoimmune Attacks
Botulism
Nerve ending
*Toxic anaerobic bacterial protease reduces ACH release
Alpha-Latrotoxin
Nerve ending
*Toxin from Black widow Spider causes massive ACh release affecting presynaptic exocytotic proteins
Beta-Bungarotoxin
Nerve ending
*Toxin in snake venom provokes ACh release followed by ACh depletion
Curare
Nerve ending
- Blocks nACHRs
- blow darts
Myasthenia Gravis
End Plate
*Chronic Autoimmune (antibodies to nAChRs)
*Loss of strength after repeated use,restoration of strength after rest
* Wider Synaptic cleft, Smaller Junctional Folds
*1st symptom is diplopia with gradual increase
*Waning
Therapies
Azathiopirine, Corticosteroid: Immunosuppressing meds
Pyridostigmine:AChE inhibitor
Thymectomy
nACHR defects
End Plate
Myathenisas
Synaptic Cleft *Present at birth signs shown before the age of 2 2 forms • Abnormal Ach bind • ACh challe brief opening time
Myotonias
Muscle Fiber
- Auto Dom.
- Lesion of the CL Channel
- increased excitability
Muscular dystrophy
Muscle Fiber
- X linked recessive -lack of Dystrophin protein
- progressive muscle weakness
Lambert-Eaton Syndrome
NMJ
- Autoimmune- Presynaptic voltage gated calcium channels
- Found in Pulm. Small cell Cancer
- Reduces ACh release
- Waxing Response
Therapy :
Plasma exchange
4-Aminoprydine (K channel Blocker) (prolong action potentials)
Leading Poisoning
Motor neuropathy Adults
Encephalopathy children younger than 6
Bilateral Weakness of extensor of fingers and wrist
Diabetes Mellitus
Stocking and glove distribution
Accompanying vasculopathy
Alcoholic Peripheral Neuropathy
Thiamin Def.
Symmetrical motor and sensory loss
Normal conduction velocity
Leprosy(Hansen Disease)
Peripheral nerve infection my Mycobacterium Leprae
Painless patch of skin followed by loss of sensation
Wasting of muscle weakness
