Drugs for Seizures Flashcards

1
Q

carbamazepine

A

Na+ channel blocker

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2
Q

valproate

A

Ca++ channel blocker, GABA agonist (inhibits GABA-T and targets succinic semialdehyde dehydrogenase), Na+ channel blocker

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3
Q

phenytoin

A

Na+ channel blocker

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4
Q

topiramate

A

Na+ channel blocker

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5
Q

lamotrigine

A

Na+ channel blocker

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6
Q

zonisamide

A

Na+ channel blocker

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7
Q

ethosuximide

A

Ca++ channel blocker

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8
Q

vigabatrin

A

GABA agonist, inhibits GABA-T

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9
Q

tiagabine

A

GABA agonist, helps GABA get backin presynaptic neuron via gat-1 transporter

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10
Q

barbituates

A

GABA agonist, targets CL- channel

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11
Q

benzodiazeprines

A

GABA agonist, targets CL- channel

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12
Q

What are downsides of GABA agonists?

A

Too sedative an effect, pt can go into withdrawl, pt can build tolerance to them

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13
Q

Why do some GABA agonists target GABA-T

A

Target GABA-T enzyme and you won’t have GABA being turned into succinic semialdehyde

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14
Q

How do sodium channel blockers work?

A

Use-dependent block

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15
Q

How do calcium channel blockers work

A

inhibit the spike-generating calcium currents by specifically blocking T type calcium channels

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