Drugs for Seizures Flashcards
carbamazepine
Na+ channel blocker
valproate
Ca++ channel blocker, GABA agonist (inhibits GABA-T and targets succinic semialdehyde dehydrogenase), Na+ channel blocker
phenytoin
Na+ channel blocker
topiramate
Na+ channel blocker
lamotrigine
Na+ channel blocker
zonisamide
Na+ channel blocker
ethosuximide
Ca++ channel blocker
vigabatrin
GABA agonist, inhibits GABA-T
tiagabine
GABA agonist, helps GABA get backin presynaptic neuron via gat-1 transporter
barbituates
GABA agonist, targets CL- channel
benzodiazeprines
GABA agonist, targets CL- channel
What are downsides of GABA agonists?
Too sedative an effect, pt can go into withdrawl, pt can build tolerance to them
Why do some GABA agonists target GABA-T
Target GABA-T enzyme and you won’t have GABA being turned into succinic semialdehyde
How do sodium channel blockers work?
Use-dependent block
How do calcium channel blockers work
inhibit the spike-generating calcium currents by specifically blocking T type calcium channels