Systemic bacterial infections 3 Flashcards

1
Q

Actinobacilus equuli general characteristics

A
  • gram neg
  • coccobacilus
  • fac anaerobe
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2
Q

actinobacillus equal natural inhabitant

A

mucous membranes in resp tract and digestive tract of horses

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3
Q

actinobacillus equuli -> what in who

A
  • sleepy foal dx
  • systemic dx older horses
  • systemic dx swine
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4
Q

sleepy foal dx signs

A
  • peracute dx: sleepy, fever, d+, prostration, rapid death

- surviving animals develop arthritis, pneumonia

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5
Q

acrinobacillus equuli older horses signs

A
  • arthritis (primarily)
  • enocarditis
  • nephritis
  • septicemia
  • inhalation can -> pneumonia
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6
Q

actinobacillus equuli swine

A
  • arthtiris(primarily)
  • endocartidits
  • nephritis
  • septicemia
  • mastitis
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7
Q

actinobacillus equuli spread

A
  • inhalation
  • ingested
  • navel (comes through navel in newborns)
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8
Q

acrtinobacillus equuli diagnosis

A
  • tissues
  • exudates
  • blood samples
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9
Q

actinobacillus equuli tx

A
  • pen/ gent
  • COLLOSTRUM= most important means of prevention
  • remove or treat infected mares
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10
Q

septicemic Escherichia coli (SEPEC) general characteristics

A
  • gram neg
  • bacillus
  • fac anaerobe
  • ZOONOTIC
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11
Q

septicemic escherichia coli natural inhabitant

A
  • intestines

- enviorment

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12
Q

septicemic escherichia coli transmission

A

fecal oral

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13
Q

septicemic escherichia coli causes what in who

A
  • bacteremia in foals, calves, lambs, piglets
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14
Q

septicemic escherichia coli signs

A
  • weak
  • +/- d+ +/- bld
  • tachycardia
  • dyspnea
  • if survive: meningitis, pneumonia, arthritis
  • USUALLY DIE W/ IN 24 HRS
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15
Q

septicemic escherichia coli pathogenesis

A
  • virulence factors let them survive outside intestinal tract -> spread systemically in newborns if ingested if newborn not protected by maternal immunity -> dx
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16
Q

septicemic escherichia coli could be mistaken for

A

sleepy foal dx presents exactly like it could easily confuse the two

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17
Q

septicemic escherichia coli zoonosis

A
  • zoonotic
  • -> dx in ppl but not GI dx -> dx if something wrong w/ person and these get into bld stream -> dx, if keep in gi tract can be perfectly healthy carrier
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18
Q

septicemic escherichia coli diagnosis

A
  • strains cultured from normally sterile sites (bld stream, jts)
  • grow rapidly in bld agar medium
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19
Q

septicemic escherichia coli tx

A
  • fluids/ electrolytes
  • various antibiotics
  • COLLOSTRUM = most important means of prevention
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20
Q

histophilus somni general characteristics

A
  • gram neg
  • fac anaerobe
  • bacillus
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21
Q

histophilus somni natural inhabitation

A

resp tract

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22
Q

histophilus somni transmission

A

inhalation

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23
Q

histophilus somni -> what in who

A
  • myocarditis
  • thrombotic meningioencephalitis
  • pneumonia
  • rarer: arthritis, otitis, spontaneous aboriton
  • cattle&raquo_space; sheep
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24
Q

histophilus somni sings in who specifically w/ cows

A
  • cattle 6-12 months
  • fall and winter
  • stress contributes to dx (see in feedlot)
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25
cattle 6-12 months histophilus somni see what
- myocarditis -> sudden death w/ no premonitory signs (more common) - TME
26
TME (thrombotic meningoencephalitis) cattle histophilus sombi signs
- depresison - blindness (eyes closed hence name somni) - ataxia - sudden death - this = more chronic dx = rare - thrombi formed in brain not elsewhere
27
histophilus somni pathogenesis
form biofilms on endothelium in various tissues in heart they cause damage to endothelium -> necrotizing lesions in cns endothelial damage -> thrombi -> ischemic necrosis of downstream tissue
28
histophilus somni lesions with histophilus myocarditis
necrotizing myocarditis | necrotizing lesions in papillary muscles of l ventricle myocardium
29
histophilus somni thrombotic meningoencephalitis lesion
- large hemorrhage in middle other hemorrhages throughout | - thrombi and ischemia
30
histophilus somni lambs
usually just septicemia
31
histophilus somni sheep
may see thrombotic meningoencephalitis
32
diagnosis histophilus somni
- necropsy | - culture bacteria from tissues
33
tx histophilus somni
- abs (la200) - metaphylaxis - vac = partial protection
34
pasturella multocida general characteristics systemic infection
- gram neg - coccobacillus - fac anerobe - pasturlla mutlocida is zoonotic but systemic infection caused by capsular serotype a which isn't really zoonotic compared to others
35
pastiruella multocida systemic infection
- fowl cholera | - avian cholera
36
signs fowl and avian cholera
- frequently find birds dead b/c of this - acute dx - chronic dx
37
acute dx avian and fowl cholera see what
- listlessness - anorexia - nasal discharge - ocular discharge - death
38
chronic dx avian and fowl cholera see what
- widespread lesions - resp signs - jt swelling -> lameness - swollen wattle
39
pasturella multocida diagnosis
- isolate from bld and grow on bld agar
40
pasturella multocida tx
- abs | - vac
41
bacillus anthracis general characteristics
- gram pos - strict aerobe - spore-forming bacillus - spores resistant - Z - R - health and human services select agents list - potential bioterrorism agent
42
bacillus anthracis natural inhabitant
soil and water
43
bacillus anthracis acquired how
ingestion
44
bacillus anthracis -> what in who
- anthrax - cattle, sheep, goats - horses - swine
45
bacillus anthracis signs ruminants
- cows, sheep, goats: - rapid death - agalactica aborption - congested mucous membranes - bloody urine and feces - edema (bc edema toxin)
46
how to handle carcas with bacillus antracis
- DO NOT OPEN bc would release spores and contaminate environment w/ spores that = last a decade + - incinerate carcass where animal dropped
47
bacillus anthracis signs horse
- colic - d+ - +/- edema
48
bacillus anthracis signs swine
- regional lymphadenitis - edema (edema can -> death if occlude airway but thats why it could -> death pigs/ (also true in horses) otherwise tends not do in them)
49
bacillus anthracis bloody urine and feces importance
IMPORTANT INDICATES ANTRHAX FOR SUDDEN DEATH OVER HISTHOPHILUS SOMNI OR CLOSTRIDIUM SO KNOW NOT TO OPEN ANIMAL FOR NECROPSY OR MOVE IT
50
bacillus anthracis seen where
- mostly upper midwest and Texas, v sporadic dx in those areas
51
bacillus anthracis diagnosis
- blood samples | - v robust big gram pos rods in chain w/ capsule
52
bacillus anthracis tx
- abs | - vac
53
bacillus anthracis control
- NOTIFY - carcasasses incinerated - tx other animals abs and vac (dnt vac till done w/ abs or abs inactivate vac) - quarantine farm w/ dx for 3 weeks after last case
54
bacillus anthracis spread
- NOT animal to animal | - pick it up form soil when spores come to surface under various conditions
55
Yersinia pestis general features
- gram neg - bipolar staining - coccobacillus - fac anaerobe - zoonotic - health and human services select agents list
56
yersinia pestis -> what in who
- plague - cats v suceptible - zoonotic - occasionally dogs get this
57
yersinia pestis natural inhabitant
tolerant hosts rodent reserviours
58
yersinia pestis transmission
- ingestion - flea bite - inhalation
59
plague variations
- bubonic plauge - septicemic plauge - pneumonic plauge
60
bubonic plague signs
- regional ln inflam and swelling | - fever, dehydration
61
septicemic plague signs
- shock - dic - fatal w/o tx
62
pneumonic plague
- fever - c+ - sneezing - rapidly fatal
63
plague pathogenesis
- bacteria ingested/ flea bite -> go to draining ln then frequently spread systemically
64
bubonic plague fatality
- if these spontaneously rupture and drain immune response will clear organisms and animal will survive - 50% time bacteria spread into bld stream and if untreated this = fatal
65
yersinia pestis diagnosis
- pus aspirated from lns - bld - grow on bld agar but are slower growing
66
bipolar staining gram neg cocobacilli
- yersinia pestis - pasturella - manhaiemia
67
yersenia pestis tx
- abs (gent for sick animals tetracycline prophylactically) - protective gear - flea control
68
coxiella burnetti general characteristics
- gram neg - obligate intracell - coccobacillus - microaerophilic - Z - R - health human services select agents list
69
coxiella burnetti -> what in who
- Q fever ppl | - sheep, goat, cattle often asymptomatic +/- aboprtion/ still birth sheep and goats and dec milk production cows
70
coxiella burnetii transmission
shed in - placenta - amniotic fluids - milk - urine - feces - carrier animals where newborns fine can shed huge numbers bacteria into environment
71
coxiella burnetti stablity
- resistant to heat, drying, common disinfectants
72
coxiella burnetti forms
- intracell replicating form (large cell variant) - extracell form (small cell variant, resistant, can be enivironment for a while, only have to inhale 1-10 to come down w/ dx)
73
burkholderia mallei general characteristics
- gram neg - bacillus - aerobic - Z - R - potential bioterrorism - us health and human services list
74
burkholderia mallei -> what in who
- glanders | - primarily in equids but many susceptible animals (not cattle, pigs, poultry)
75
burkholderia mallei found where
eliminated from us
76
u=burkholderia mallei acute dx see what in who
- donkeys and mules | - fever, nasal discharge, lymphadenitis of head and neck
77
burkholderia mallei transmission
- ingestion nasal discharge for spread btwn equi
78
burkholderia mallei chronic dx see what in who
- horses - pulmonary: cough, epistaxis, labored breathing - nasal: nodular lesions on turbinates, enlarged lns - skin: sq nodules, enlarged lns
79
burkholderia pseudomallei characteristics
- gram neg - bacillus - aerobic - Z - R - potential bioterrorism - us health and human services list
80
burkholderia pseudomallei see what in who
- melioidosis - horses: dx similar to glanders - goats, pigs- chronic - rodents and sheep- neuro; usually fatal - z
81
burkholderia pseudomallei location
- south east asia | - australia
82
burkholderia pseudomallei diangosis
- exudates from lesions | - grows on bld agar
83
burkholderia spp. tx
- tetracycline works but bc z potential infected animals mainly killed
84
glanders us
eradicated via test and cull program
85
glanders found where
Middle East and asia
86
meleroidosis vs glanders
can eliminate glanders but not meleroidosis bc meleroidosis found in environment too
87
when see actinobacillus arthritis/ endocardidits/ septicemic in older horses and pigs
after stress
88
actinobacillus equuli and septicemic escherichia coli effect newborn animals who have had a
failure of passive transfer
89
histophilus somni mainly causes what systemically
- myocarditis in cattle | - also -> pneumonia and thrombotic meningoencephalitis