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Herpes Flashcards

1
Q

what type of virus is herpes

A

enveloped ds dna

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2
Q

herpesvirus in cattle

A
  • infectious bovine rhinotracheitis (ibr), infectious pustular vulvovaginitis and infectious bovine ballon-phostititis (BHV1)
  • bovine mammilitis (bhv-2)
  • malignant catarrhal fever (aihv-1 and ohv-2)
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3
Q

herpesviruses in horses

A
  • equine herepes myeloencephalitis (EHM), equine aborition virus (Ehv-1)
  • rhinopneumonoitis (Ehv-4)
  • equine coital exanthema (Ehv-3)
  • equine gammaherpes viruses (ehv-2 and ehv-5)
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4
Q

bovine herepes virus 1 type and natural host

A

alpha, cow

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5
Q

bovine herpes virus 2 type and natural host

A

alpha, cow

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6
Q

alcelaphine herpesvirus 1 type and natural host

A

gama, wildebeest

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7
Q

ovine herpesvirus 2 type and natural host

A

gama, sheep

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8
Q

pseudorabies virus type and natural host

A

alpha, pig

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9
Q

most common virus infection of cattle

A

bovine herpesvirus type 1

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10
Q

bovine herpes virus 1 causes what

A
  • respiratory entry -> infectious bovine rhinotracheitis and aborition
  • genital entry -> pustular vulvovaginitis (ipv) and infectious balanoposthititis (Ibp)

low mortality

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11
Q

bovine herpes virus type 1 pathogenesis infectious bovien rhinotracheitis

A
  1. primary rep in mucosal surfaces (resp)
  2. viremia
  3. abortion and or latency in trigem ganglion
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12
Q

bovine herpes virus type 1 pathogenesis genital route

A
  1. primary replication in mucosal surface (genitals)
  2. genital local signs NO viremia
  3. +/- latency in sacral ganglion
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13
Q

clinical signs bovine herpesvirus type one infectious bovine rhinotrachietis

A
  • upper resp signs
  • fetid odor breath (oronasal ulcers)
  • oronasal secretions
  • aborition
  • rarely encephalitis young calves
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14
Q

clinical signs bovine herpes virus type 1 IPV signs

A
  • fever/ depression/ inappetance
  • vesicles or pustules on vulvar skin, vaginal mucosa
  • ulcerations vaginal mucosa
  • frequent micturition
  • tail held away from vulva
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15
Q

bovine herpes virus type 1 IBP clinical signs

A
  • balanatis (inflam glans penis)
  • posthititis (inflammation of prepuce)
  • vesicles to ulcers
  • bulls won’t breed
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16
Q

bovine herpesvirus type 1 hard to differentiate from

A

other common causes bovine respiratory dx complex

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17
Q

bovine herpesvirus type 1 prevention

A
  • sterilize ai equipment, virus free semen
  • steroids to reactive virus so can id carrier pulls
  • don’t ship infected cattle with pregnant cattle bc stress -> reactivate
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18
Q

vac preg cattle for bovine herpes virus type 1

A

NO parenteral mlv intranasal okay

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19
Q

bovine herpes virus 2 causes what in us vs Africa

A 
us
- bovine mammilitis (bhm)
africa 
- bovine mammilitis (bhm)
- pseudo lumpy skin dx (plsd)
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20
Q

pathogenesis bovine herpes virus type 2

A

unk but insects and fomites play role in transmission

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21
Q

clinical signs pseudo lumpy skin dx

A
  • oedematous nodules neck, back head chest, tail region
  • nodules = painful
  • scab formation
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22
Q

clinical signs bovine mammilitis

A
  • skin lesions on teat and udder only of lactating cows
  • ulceration of skin of mammary gland
  • teat pain and swelling -> can’t milk -> dec milk production and bacterial mastitis bc retention of milk
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23
Q

bovine herpes virus type 2 biopsy

A

intranuclear incursions, hydronic degeneration of skin cells

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24
Q

bovine herpes virus type 2 vac

A

none

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25
malignant catarrhal fever general features, in who, what type virus
- fatal in cattle, deer, antilope, buffalo | - gamma herpes virus
26
malignant catarrhal fever what causes it
causes: - alcelaphine herpesvirus type 1 (AIHV-1) natural host = wildebeest - ovine herpesvirus type 2 (OHV-2) natural host = sheep
27
reportable herpes dxs cows and horses
- malignant catarrhal fever (some states) | - ehv-1 some states
28
malignant catarrhal fever sigsns natural host
none
29
malignant catarrhal fever caused by alcelaphine herpesvirus type 1 epidemiology (where morbidity/ mortality)
- in africa and zoos | - morbidity cattle v low, mortality v high (fatal)
30
malignant catarrhal fever caused by alcelaphine herpesvirus type 1 transmission
- close contact of cows and natural reservoirs around calving time - DOES NOT spread cow to cow
31
malignant catarrhal fever (MCF) caused by ovine herpes virus 2 found where, natural host, transmission
- western us | - transmission to cattle when close contact w/ sheep especially around lambing time
32
malignant catarrhal fever pathogenesis
``` -primary infection -> resp signs lymphocyte associated -viremia -> lymphadenopathy - T lymphocyte hyperplasiaa - secondary replication in endothelial cells -> vascultis ```
33
malignant catarrhal fever clinical signs
- profuse nasal and ocular discharge - lymphadenopathy - mucosal erosions bilateral ophthalmia (pathognomonic) -> blindness - DEATH
34
lesions malignant catarrhal fever
- vasulitis - ln edematous +/- hemorrhagic - erosions nasal turbinate, larynx, gut
35
malignant catarrhal fever histo
- lymphoid cell proliferation
36
malignant catarrhal fever vac
none
37
bovine respiratory dx complex aka
shipping fever
38
etiologic causes gammaherpes viruses
- aihv-1 (wildebeet) - ohv-2 (sheep) * herpes virus = malignant catarrhal fever*
39
herpesviruses in horses
- Equine herpes virus 1 - equine herpes virus 2 - equine herpes virus 3 - equine herpes virus 4 - equine herpes virus 5
40
what equine herpes viruses are related
- ehv1, ehv4 | - ehv2, ehv5
41
equine herpes virus 1 virus type
alphaherpes virus
42
equine herpes virus 1 spread
widespread but equine herpes virus 4 = more widespread
43
equine herepes virus 1 can ->
- neurologic dx | - aboritions storms
44
equine herpes virus 1 latency
- in neurons and immune cells
45
pathogenesis of equine herpes virus 1
- primary infection -> resp signs - viremia -> viral replication in endothelial cells -> either 1. pregnant uterus -> aborition of virus neg fetus; if less severe -> aborition of virus positive fetus 2. spinal cord thrombosis -> lower spinal cord necrosis -> hind limb ataxia
46
neurological signs equine herpes virus type 1
NOT caused by viral replication in neurons caused by virus replicating in endothelial cells -> issues in lower spinal cord NOT replication in neurons (endotheliotropic herpesvirus NOT neurotropic)
47
how get virus neg vs virus pos fetus
- thrombosis and vasculitis can be so severe -> aborition of virus- neg fetus, if virus infection less severe more time for virus to replicate then can reach fetus and can have aboprtion of virus positive fetus
48
equine herpes virus type 1 clinical signs
- fever (sometimes biphasic) - nasal discharge - neuro signs (usually hindlimb ataxia) - aboritions last 4 months of pregnancy, sudden w/o premonitory signs - aborted fetus = fresh or minimally autolized
49
mare post aboriton bc equine herpes virus type 1
mare fine to mate again and become preganant again
50
a term born foals equine herpes virus type 1
fulminating viral pneumonitis | -> bacterial infections -> death
51
equine herpes virus lesion dvisions
- viral pneumonitis - env-1+ aborted fetus - EHM (equine herpes myeloecephalopathy)
52
equine herpes virus type 1 viral pneumonitis lesion
- hyperemia and ulcerations resp epithelium | - must tiny plum-colored foci in lungs
53
ehv1 positive aborted fetus lesions
- lung edema, pleural fluid - hepatic and thyme necrosis - petechial lesions various organs - intranucelar viral inclusinos
54
equine herpes virus type 1 lesions ehm
- no gross lesions | - histo discrete lesions of vasculitis w/ endothelial cell damage and perivascular cuffing
55
equine herpes virus 1 neuro animals regain fx?
many will some dont
56
ehv1 control
- vac - quarantine - isolation of sick/ infected animals
57
ehv-4 virus type
alphaherpes virus
58
ehv-4 spread (how frequent is it)
endemic in horse populations worldwide
59
ehv4 -> what
urt signs in young horses
60
ehv-4 pathogenesis
urt dx; doesn't cause viremia so clinical signs in urt only
61
ehv-4 clinical signs
-
62
ehv-4 clinical signs
- mild to severe urt signs - profuse nasal discharge - nasal discharge = mucopurulent w/ secondary bacterial infeciton - lwr lung dx possible
63
ehv4 vac
- reduces severity of clinical signs
64
equine herpes virus 3 causes what
equine coital exanthema
65
equine herpes virus 3 transmission
sexual contact
66
equine herpes virus 3 incubation time
v short
67
equine herpes virus 3 incubation time
v short
68
equine herpes virus 3 pathogenesis
- primary infection genital mucosa -> primary lesions - does not cause viremia - recurrent dx = possible - open sores = virus shedding
69
equine herpes virus type 3 clinical signs stallion
- pustules and ulcerations of penis and prepuce
70
equine herpes virus 3 clinical signs mares
pustules and ulcerations on vagina, perineum, lips, and teats lesions heal w. in 2 weeks
71
equine herpes virus 3 vac
none
72
equine herpes virus type 2 virus type
gammaherpes virus
73
equine herpes virus 2 how widespread in hores
- v widespread
74
equine herpes virus 5 spread
less widespread than ehv-2
75
ehv5 causes
equine multi nodular pulmonary fibrosis

block 4 (23 decks)

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