Herpes Flashcards
what type of virus is herpes
enveloped ds dna
herpesvirus in cattle
- infectious bovine rhinotracheitis (ibr), infectious pustular vulvovaginitis and infectious bovine ballon-phostititis (BHV1)
- bovine mammilitis (bhv-2)
- malignant catarrhal fever (aihv-1 and ohv-2)
herpesviruses in horses
- equine herepes myeloencephalitis (EHM), equine aborition virus (Ehv-1)
- rhinopneumonoitis (Ehv-4)
- equine coital exanthema (Ehv-3)
- equine gammaherpes viruses (ehv-2 and ehv-5)
bovine herepes virus 1 type and natural host
alpha, cow
bovine herpes virus 2 type and natural host
alpha, cow
alcelaphine herpesvirus 1 type and natural host
gama, wildebeest
ovine herpesvirus 2 type and natural host
gama, sheep
pseudorabies virus type and natural host
alpha, pig
most common virus infection of cattle
bovine herpesvirus type 1
bovine herpes virus 1 causes what
- respiratory entry -> infectious bovine rhinotracheitis and aborition
- genital entry -> pustular vulvovaginitis (ipv) and infectious balanoposthititis (Ibp)
low mortality
bovine herpes virus type 1 pathogenesis infectious bovien rhinotracheitis
- primary rep in mucosal surfaces (resp)
- viremia
- abortion and or latency in trigem ganglion
bovine herpes virus type 1 pathogenesis genital route
- primary replication in mucosal surface (genitals)
- genital local signs NO viremia
- +/- latency in sacral ganglion
clinical signs bovine herpesvirus type one infectious bovine rhinotrachietis
- upper resp signs
- fetid odor breath (oronasal ulcers)
- oronasal secretions
- aborition
- rarely encephalitis young calves
clinical signs bovine herpes virus type 1 IPV signs
- fever/ depression/ inappetance
- vesicles or pustules on vulvar skin, vaginal mucosa
- ulcerations vaginal mucosa
- frequent micturition
- tail held away from vulva
bovine herpes virus type 1 IBP clinical signs
- balanatis (inflam glans penis)
- posthititis (inflammation of prepuce)
- vesicles to ulcers
- bulls won’t breed
bovine herpesvirus type 1 hard to differentiate from
other common causes bovine respiratory dx complex
bovine herpesvirus type 1 prevention
- sterilize ai equipment, virus free semen
- steroids to reactive virus so can id carrier pulls
- don’t ship infected cattle with pregnant cattle bc stress -> reactivate
vac preg cattle for bovine herpes virus type 1
NO parenteral mlv intranasal okay
bovine herpes virus 2 causes what in us vs Africa
us - bovine mammilitis (bhm) africa - bovine mammilitis (bhm) - pseudo lumpy skin dx (plsd)
pathogenesis bovine herpes virus type 2
unk but insects and fomites play role in transmission
clinical signs pseudo lumpy skin dx
- oedematous nodules neck, back head chest, tail region
- nodules = painful
- scab formation
clinical signs bovine mammilitis
- skin lesions on teat and udder only of lactating cows
- ulceration of skin of mammary gland
- teat pain and swelling -> can’t milk -> dec milk production and bacterial mastitis bc retention of milk
bovine herpes virus type 2 biopsy
intranuclear incursions, hydronic degeneration of skin cells
bovine herpes virus type 2 vac
none
malignant catarrhal fever general features, in who, what type virus
- fatal in cattle, deer, antilope, buffalo
- gamma herpes virus
malignant catarrhal fever what causes it
causes:
- alcelaphine herpesvirus type 1 (AIHV-1) natural host = wildebeest
- ovine herpesvirus type 2 (OHV-2) natural host = sheep
reportable herpes dxs cows and horses
- malignant catarrhal fever (some states)
- ehv-1 some states
malignant catarrhal fever sigsns natural host
none
malignant catarrhal fever caused by alcelaphine herpesvirus type 1 epidemiology (where morbidity/ mortality)
- in africa and zoos
- morbidity cattle v low, mortality v high (fatal)
malignant catarrhal fever caused by alcelaphine herpesvirus type 1 transmission
- close contact of cows and natural reservoirs around calving time
- DOES NOT spread cow to cow
malignant catarrhal fever (MCF) caused by ovine herpes virus 2 found where, natural host, transmission
- western us
- transmission to cattle when close contact w/ sheep especially around lambing time
malignant catarrhal fever pathogenesis
-primary infection -> resp signs lymphocyte associated -viremia -> lymphadenopathy - T lymphocyte hyperplasiaa - secondary replication in endothelial cells -> vascultis
malignant catarrhal fever clinical signs
- profuse nasal and ocular discharge
- lymphadenopathy
- mucosal erosions
bilateral ophthalmia (pathognomonic) -> blindness - DEATH
lesions malignant catarrhal fever
- vasulitis
- ln edematous +/- hemorrhagic
- erosions nasal turbinate, larynx, gut
malignant catarrhal fever histo
- lymphoid cell proliferation
malignant catarrhal fever vac
none
bovine respiratory dx complex aka
shipping fever
etiologic causes gammaherpes viruses
- aihv-1 (wildebeet)
- ohv-2 (sheep)
- herpes virus = malignant catarrhal fever*
herpesviruses in horses
- Equine herpes virus 1
- equine herpes virus 2
- equine herpes virus 3
- equine herpes virus 4
- equine herpes virus 5
what equine herpes viruses are related
- ehv1, ehv4
- ehv2, ehv5
equine herpes virus 1 virus type
alphaherpes virus
equine herpes virus 1 spread
widespread but equine herpes virus 4 = more widespread
equine herepes virus 1 can ->
- neurologic dx
- aboritions storms
equine herpes virus 1 latency
- in neurons and immune cells
pathogenesis of equine herpes virus 1
- primary infection -> resp signs
- viremia -> viral replication in endothelial cells -> either
1. pregnant uterus -> aborition of virus neg fetus; if less severe -> aborition of virus positive fetus
2. spinal cord thrombosis -> lower spinal cord necrosis -> hind limb ataxia
neurological signs equine herpes virus type 1
NOT caused by viral replication in neurons caused by virus replicating in endothelial cells -> issues in lower spinal cord NOT replication in neurons (endotheliotropic herpesvirus NOT neurotropic)
how get virus neg vs virus pos fetus
- thrombosis and vasculitis can be so severe -> aborition of virus- neg fetus, if virus infection less severe more time for virus to replicate then can reach fetus and can have aboprtion of virus positive fetus
equine herpes virus type 1 clinical signs
- fever (sometimes biphasic)
- nasal discharge
- neuro signs (usually hindlimb ataxia)
- aboritions last 4 months of pregnancy, sudden w/o premonitory signs
- aborted fetus = fresh or minimally autolized
mare post aboriton bc equine herpes virus type 1
mare fine to mate again and become preganant again
a term born foals equine herpes virus type 1
fulminating viral pneumonitis
-> bacterial infections -> death
equine herpes virus lesion dvisions
- viral pneumonitis
- env-1+ aborted fetus
- EHM (equine herpes myeloecephalopathy)
equine herpes virus type 1 viral pneumonitis lesion
- hyperemia and ulcerations resp epithelium
- must tiny plum-colored foci in lungs
ehv1 positive aborted fetus lesions
- lung edema, pleural fluid
- hepatic and thyme necrosis
- petechial lesions various organs
- intranucelar viral inclusinos
equine herpes virus type 1 lesions ehm
- no gross lesions
- histo discrete lesions of vasculitis w/ endothelial cell damage and perivascular cuffing
equine herpes virus 1 neuro animals regain fx?
many will some dont
ehv1 control
- vac
- quarantine
- isolation of sick/ infected animals
ehv-4 virus type
alphaherpes virus
ehv-4 spread (how frequent is it)
endemic in horse populations worldwide
ehv4 -> what
urt signs in young horses
ehv-4 pathogenesis
urt dx; doesn’t cause viremia so clinical signs in urt only
ehv-4 clinical signs
-
ehv-4 clinical signs
- mild to severe urt signs
- profuse nasal discharge
- nasal discharge = mucopurulent w/ secondary bacterial infeciton
- lwr lung dx possible
ehv4 vac
- reduces severity of clinical signs
equine herpes virus 3 causes what
equine coital exanthema
equine herpes virus 3 transmission
sexual contact
equine herpes virus 3 incubation time
v short
equine herpes virus 3 incubation time
v short
equine herpes virus 3 pathogenesis
- primary infection genital mucosa -> primary lesions
- does not cause viremia
- recurrent dx = possible
- open sores = virus shedding
equine herpes virus type 3 clinical signs stallion
- pustules and ulcerations of penis and prepuce
equine herpes virus 3 clinical signs mares
pustules and ulcerations on vagina, perineum, lips, and teats
lesions heal w. in 2 weeks
equine herpes virus 3 vac
none
equine herpes virus type 2 virus type
gammaherpes virus
equine herpes virus 2 how widespread in hores
- v widespread
equine herpes virus 5 spread
less widespread than ehv-2
ehv5 causes
equine multi nodular pulmonary fibrosis