Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

block 4 > Flaviviruses, pestiviruses, alphaviurses > Flashcards

Flaviviruses, pestiviruses, alphaviurses Flashcards

1
Q

genus in flaviriridae family

A
  • flaviviruses

- pestiviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

flaviviruses

A
  • west nile virus
  • St. Louis encephalitis virus
  • wesselbron dx
  • yellow fever dx
  • tick borne encephalitis
  • looping III
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

pestiviruses

A
  • bovine viral diarrhea
  • border dx
  • hog cholera (classical swine fever)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

togaviruses

A
  • eastern, wester, venezulenan encephalitis viruses
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

flaviviridae features

A
  • enveloped virus
  • e protein
  • ssrna
  • positive sense
  • 1 long open reading frame
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

flaviviridae genome features

A
  • 5’ end of genome capped, 3’ end no poly a (5’ like mammalian genome, 3’ diff than mammalian protein)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

flavivirdae host

A

broad host insect and vertebrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

st louis encephalitis virus type

A

flavivirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

st loud encephalitis

A
  • mosquito-bird-mosquioto cycle

- causes signficant human dx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

wesselsbron virus type

A

flavivirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

wesselsbron virus affects who

A
  • sheep mainly

- cattle, horses, swim sub clinically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

wesselbron virus sheep where and signs

A
  • in subsaharan africa
  • fever, jaundice, sq edema
  • abortion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

zoonotic flaviviruses

A
  • St. Louis encephalitis
  • wesselbron dx
  • louping III
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

west nile virus transmission

A
  • mosquito transmitted virus ‘
  • maintained in birds
  • transmitted to horses and humans
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

west nile virus in us

A

endemic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

horses and humans and west nile relatinoship

A
  • these are dead end hosts for virus virus does not aim to get into human or horse goes from insect to mammal
  • don’t really see horse to horse or human to human transmission
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

west nile virus horses presentation

A
  • most susceptible to infection and dx
  • most = subclinical infections
  • clinical- see cns signs
  • 1/3 clinical horses die
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

diagnosis of westnile in horses and contaminant level

A
  • fa of infected tissues or csf

- bl3 contaminant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

why use igm vs igg for serology

A
  • advantage to igm is that you detect it sooner
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

westnile virus vac available

A
  • inactivate vac in horses = good efficacy (canarypox virus vectored subunit vac)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

flavivirus transmitted by tick

A
  • powassan virus in North America

- louping III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

flavivirus transmitted by tick infection and replication

A
  • infect small mammals
  • replicate in ticks
  • bld meal at every stage so every meal = chance to transmit
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

flavivirus transmitted by tick transmission

A
  • transtadially(through insect stages)

- transovarially (through eggs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

louping III virus type

A

flavivirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
louping III causes what
infectious encephalomyelitis of sheep
26
louping III affects who
- sheep primarily | - horse, cattle, deer
27
louping III in sheep
- infectious encephalomyelitis of sheep - sheep = viremia, biphasic febrile response - 2nd stage = enter cns -> neuro
28
louping III vac?
yes, inactivated
29
flaviviruses general patterns
- broad hosts and cell tropism including insect and ertebrate - many are zoonotic and affect cns - many have vaccines that work against them
30
westnile mortiality
- 5% humans | 33% horses
31
bovine viral diarrhea virus type
- pestivirus genus within flaviviridae family
32
bvd starins
- 2 strains - type 1 - type 2 - antigenic cross protection btwn two virus types
33
type 1 bvd
mild dx
34
type 2 bvd
more seere dx
35
bovine viral diarrhea affects who
- post natal infection in non-preg cattle - pregnant cattle - sheep, deer, bison, wild ruiinnts
36
bovine viral diarrhea post natal infection in non-pregnant cattle -> ?
- GI tract dx - mucosal dx - fever - leukopenia - occular/ nasal discharge - erosive stomatitis - lwr milk production - immunosuppression -> secondary infections
37
bovine viral diarrhea pregnant cattle -> ?
``` if transplacental transmission - fetal death - low birth weight - retinal dysplasia - cerebellar dx if persistently infected for life - immune tolerant, shed virus - +/- mucosal dx later in life ```
38
if bovine viral diarrhea infects calves > 125 days of gestation
clear the virus
39
cytopathic biotype bovine viral diarrhea
- SEVERE - anorexia - profuse watery d+ - nasal discharge - erosive/ ulcerative sotmatitis - death
40
bovine viral diarrhea pathogenesis in normal cattle
mild wide growing virus can -> GI ulcers
41
histology bovine viral diarrhea
- destruction of gi tract at various levels - mucosal dx in persistently infected animals - cerebellar lesions!
42
bovine diarrheal virus diagnosis
- hx - path lesions - non-cytopathic so use antibody staining
43
bovine viral diarrhea epidemiology (spread, level of consistent infection)
- direct and indirect contact | - persistently infected have high levels of virus
44
bovine diarrheal virus vac
- yes | - modified live can -> inected cattle getting mucosal dx
45
border dx of sheep what kind of virus
- pestivirus genus within flaviviridae family
46
border dx of sheep affects who
``` adult sheep - subclinical infectin fetal infection - dead -deformed -mummified lambs **congenital dx in lambs** -low birthweight -poor viability -hairy shakers ```
47
pathogenesis border dx of sheep
- defective myelination of nerve fibers in cns | - tolerant persistent infection = possible
48
control border dx of sheep
- be careful of what introduce where and when and what you test and if you have immune prepared popuation you are introducing new animals to
49
diagnosis border dx of sheep
- hx - path lesions - non-cytopathic so use antibody staining
50
classic swine fever/ hog cholera virus type
- pestivirus genus within flaviviridae family
51
classic swine fever/ hog cholera virus type
- gi - cns - fever - conjunctivitis - pneumonia
52
classi swine fever/ hog cholera virus type signs
- diffuse hyperemia - purport abdomen and ears - gi - cns
53
classic swine fever/ hog cholera w/ in a herd
- many pigs in herd ill - young may die or become lifelong shedders - older pigs secondary bacterial infections -> 100% mortality
54
hog cholera pathogenesis
- oronasal infection infect lymphoid organs and endothelial cells - can severely affect most major organs - V BAD DX
55
hog cholera lesions
- hemorrhages - leukopenia - thrombocytopenia - infarctions - DIC - encephalitis w/ perivascular cuffing
56
hog cholera chronic cases
- necrotic lesions large intestinal mucosa - bacterial infection of lungs - atophy of lymphoid tissues
57
hog cholera persistently infected piglets
- can be immune tolerant and lifelong shedders
58
diagnosis of hog cholera
- hx - path lesions - non-cytopathic so use antibody staining
59
hog cholera transmission
- contact btwn swine - indirect transport of virus - can survive in frozen pork
60
control hog cholera
- test and slaughter policy | - vac effective (attenuated)
61
pestiviruses general
- genus of flaviviridae fam - positive sense ssRNA - one open reading frame
62
togaviradae family members and surface contains what
- alpha viruses (30 members) | - spikes 2 glycoprotein (E1 and E2)
63
togavirade family general features
- envelope - ssRNA - positive polarity - 5' methylated cap and poly-a
64
togaviridae rna genome
- subgeneric rna encoding structural proteins
65
togaviridae affects who and affect on their cells
- insect, avian, and mammalian cells - kills mammalina cells - less effect on insect cells
66
alphavirus what kind of virus
-togaviridae
67
alphavirus types of viruses
- eastern equine encephalitis - western equine encephalitis - venezuelan equine encephalitis
68
eastern and western equine encephalitis presntiaton
- subclinical or | - fever, anorexia, depression, neuro signs
69
venezuelan equine encephalitis presentaiton
- systemic dx | - fewer neuro signs that EEE, WEE
70
wee, eee, vee fatality level
HIGH fatality levels
71
pathogenesis alphavirus
- mosquito bite -> virus to local lymphoid tissue -> systemic spread -> replicate -> CNS -> neuronal necrosis
72
immunity if survive alphavirus
long lived IF survive
73
alphavirus vac
- yes | - inactivated and attenuated
74
eastern equine encephalitis seasonality / maintained how
- seasonal w/ vectors | - maintained in birds
75
venezuelan equine encephalitis cycle
- mosquitos and small mammals
76
eee found where
endemic north America, central and norther south america
77
wee found whree
widely distributed in plains and west in birds and mosquitos
78
vet found where
endemic in venezuela Colombia and peru
79
alphavirus spread
epidemics can spread rapidly

block 4 (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions