Steroidal Anti-inflammatory Flashcards
1
Q
what is the suffix used for Glucocorticoids
A
(-“sone”)
1
Q
what is the function of SAIDs or Glucocorticoids
A
1) control glucose metabolism
2) controls the bodies ability to deal with stress
3) decreases inflammation
4) suppresses the immune system
2
Q
what do SAIDs or Glucocorticoids bind to
A
GRE (glucocorticoids response elements) in the nucleus altering gene expression
3
Q
what conditions are glucocorticoids used for
A
1) endocrine
2) non endocrine (msk or immunosuppressive)
4
Q
what are the adverse effects of glucocorticoids
A
A: adrenal shock/ Adrenocortical suppression
B: breakdown of tissues
C: Cushing syndrome
D: decrease in Ca2+ absorption
5
Q
what can adrenal crises/ shock lead to
A
- vasodilation of the organs
- vascular collapse
- hypotension
6
Q
what are the symptoms of cushing syndrome (hypercortisalism)
A
- roundness of the face
- fat deposition and obesity in the trunk
- muscle wasting in the extremities
- osteoporosis
- increased body hair
- glucose intolerance
