anti depressants and bi polar disorder drugs Flashcards
what are the 1st generation anti depressants
Tricyclic antidepressants (TCAs) and MOA inhibitors
what are the 2nd generation anti depressants
- selective serotonin reuptake inhibitors
- serotonin and NE reuptake inhibitors
- NE and dopamine reuptake inhibitors
selective seretonin reuptake inhibitor drugs
-lopram, fluoxetine, sertraline
what is the MOA of selective seretonin reuptake inhibitor
inhibition of 5-HT transporters
what are the side effects of selective seretonin reuptake inhibitors
- sexual
- somnolence
- insomnia
- headache
- hyponatremia
what are the drugs that are serotonin and NE reuptake inhibitors
-lafaxine and -oxetine
what is the MOA of serotonin and NE reuptake inhibitors
inhibit serotonin and NE transporters
what are the side effects of serotonin and NE reuptake inhibitors
- sexual
- somnolence
- insomina
- headache
- hypoatemia
- increase HR and dry mouth
what drug is a dopamine and NE reuptake inhibitor
Bupropion
what are the side effects of bupropion
- insomnia
- tremors
- seizures
- wt loss
what is the suffix for Tricyclic antidepressents
-triptyline
what is the side effects of tricyclic antidepressents
- QT prolongation
- orthostatic hypotension and tachycardia
- anticholinergic effects
- vivid dreams
- wt gain
what are the drugs that are MOA inhibitors
1) monclobemide
2) phenelzine
what is the MOA of monclobemide
reversible inhibition of monamine oxidase
what is the MOA of phenelzine
irreversible inhibition of MAO
what are the side effects of MOA inhibitors
- sedation
- orthostatic hypotension
- sexual dysfunction
- hypertensive crisis
what food to avoid with MOA inhibitors
tyramine
indication for Braxanolone
post partum depression
what is the MOA of braxanolone
modulate GABAa receptors and increase 5 HT and NE transmission
what are the side effects of braxanolone
- headache
- somnolence
- dizziness
drugs for manic bi polor
lithium and diualproex
what is the MOA of manic bi polar drugs
- neuroprotection
- neurotransmitter modulation
- inhibition of phosphate 3
what are the acute side effects of manic bi polar drugs
- nausea
- diarrhea
- lethargy
- impaired cognitive dysfunction
- hand tremor
what are the long term side effects of manic bi polar drugs
- hypothyroidism
- cardiac effects
- wt gain
- leukocytosis
- dermatological effects
drugs used for depression in bi polar
1) lithium
2) lamotrigine
3) aripiprazole
4) quetiapine
5) risperidone
