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Pharmacology > anti depressants and bi polar disorder drugs > Flashcards

anti depressants and bi polar disorder drugs Flashcards

1
Q

what are the 1st generation anti depressants

A

Tricyclic antidepressants (TCAs) and MOA inhibitors

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2
Q

what are the 2nd generation anti depressants

A
  • selective serotonin reuptake inhibitors
  • serotonin and NE reuptake inhibitors
  • NE and dopamine reuptake inhibitors
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3
Q

selective seretonin reuptake inhibitor drugs

A

-lopram, fluoxetine, sertraline

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4
Q

what is the MOA of selective seretonin reuptake inhibitor

A

inhibition of 5-HT transporters

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5
Q

what are the side effects of selective seretonin reuptake inhibitors

A
  • sexual
  • somnolence
  • insomnia
  • headache
  • hyponatremia
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6
Q

what are the drugs that are serotonin and NE reuptake inhibitors

A

-lafaxine and -oxetine

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7
Q

what is the MOA of serotonin and NE reuptake inhibitors

A

inhibit serotonin and NE transporters

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8
Q

what are the side effects of serotonin and NE reuptake inhibitors

A
  • sexual
  • somnolence
  • insomina
  • headache
  • hypoatemia
  • increase HR and dry mouth
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9
Q

what drug is a dopamine and NE reuptake inhibitor

A

Bupropion

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10
Q

what are the side effects of bupropion

A
  • insomnia
  • tremors
  • seizures
  • wt loss
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11
Q

what is the suffix for Tricyclic antidepressents

A

-triptyline

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12
Q

what is the side effects of tricyclic antidepressents

A
  • QT prolongation
  • orthostatic hypotension and tachycardia
  • anticholinergic effects
  • vivid dreams
  • wt gain
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13
Q

what are the drugs that are MOA inhibitors

A

1) monclobemide
2) phenelzine

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14
Q

what is the MOA of monclobemide

A

reversible inhibition of monamine oxidase

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15
Q

what is the MOA of phenelzine

A

irreversible inhibition of MAO

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16
Q

what are the side effects of MOA inhibitors

A
  • sedation
  • orthostatic hypotension
  • sexual dysfunction
  • hypertensive crisis
17
Q

what food to avoid with MOA inhibitors

A

tyramine

18
Q

indication for Braxanolone

A

post partum depression

19
Q

what is the MOA of braxanolone

A

modulate GABAa receptors and increase 5 HT and NE transmission

20
Q

what are the side effects of braxanolone

A
  • headache
  • somnolence
  • dizziness
21
Q

drugs for manic bi polor

A

lithium and diualproex

22
Q

what is the MOA of manic bi polar drugs

A
  • neuroprotection
  • neurotransmitter modulation
  • inhibition of phosphate 3
23
Q

what are the acute side effects of manic bi polar drugs

A
  • nausea
  • diarrhea
  • lethargy
  • impaired cognitive dysfunction
  • hand tremor
24
Q

what are the long term side effects of manic bi polar drugs

A
  • hypothyroidism
  • cardiac effects
  • wt gain
  • leukocytosis
  • dermatological effects
25
Q

drugs used for depression in bi polar

A

1) lithium
2) lamotrigine
3) aripiprazole
4) quetiapine
5) risperidone

Pharmacology (24 decks)

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