Anti-anginal Drugs Flashcards
what are the different drug classes used for angina
1) Nitrates (nitrate)
2) Beta blockers (olol)
3) CCB (pines, vera, and diltia)
4) Sodium channel blockers (Ranolzine)
what is the MOA of nitrates
release nitric oxide which increases cGMP and promotes vasodilation of smooth muscle
what are the common side effects of nitrates
- headache
- orthostatic hypotention
- flushing
- tachycardia
- nausea
what are the clinical uses for nitrates
- acute angina relief
- angina prophylaxis
- heart failure
- acute coronary syndromes
what is the MOA of beta blockers
inhibit Beta 1 recepters to decrease HR and BP
what are the common side effects of beta blockers
- fatigue
- bradycardia
- hypotension
- bronchospasm
what are the clinical indications for beta blockers
- angina
- HTN
- arrhythmia
- HF
what is the MOA of CCB
inhibit calcium influx to promote vasodialtion
what are the common side effects of CCB
- dizziness
- headache
- flushing
- edema
- constipation
what are the clinical uses for CCB
- Angina
-HTN - Arrhythmias
what is the MOA of Ranolazine
modulate sodium and calcium channels to reduce cardiac oxygen demand
what are the common side effects of Ranolazine
- dizziness
- headache
- consitpation
- QT interval prolongation
what is the clinical use for Ranolazine
- chronic angina management ( used when first line medications are not working anymore)
