Drugs for Asthma and COPD Flashcards
drugs for ASTHMA
A= adrenergics
S= steroids
T= Theophylline
H= hydration and O2 supplementation
M= Laukotrine modifiers
A= anticholinergic
what are the short acting beta 2 agonists
albuterol and levabuterol
what is the common MOA of beta 2 agonists
brochodilation
what are the common side effects of beta 2 agonists
tachycardia, palpitations, tremors, nervousness
what are the long acting beta agonists
salmeterol and formoterol
what are the clinical use for short acting beta 2 agonists
actue asthma S/S
what are the clinical use for long acting beta 2 agonist
long term ashma use
what is the suffix for corticosteroids
( sone or sonide)
what is the MOA of corticosteriords
anti-inflammatory; reduce airway inflammation
what is the clinical use for corticosteroids for asthma pts
maintenance therapy to prevent exasterbations
what are the side effects for corticosteriods
- oral thrush
- osteoporosis
- wt gain
- increased risk for infection
- muscle wasting
what is the MOA of theophylline
caffeine use to relax bronchi
what is the suffix for leukotrine modifiers
leukotriene receptor agonist (-lukast)
5-lipoxygenase inhibitor (zileuton)
what is the MOA of leukotriene modifiers
block leukotriene receptors or inhibit their synthesis
what are the side effects for leukotriene modifiers
- headache
- nausea
- mood changes
what are the drugs that are anticholinergic
the bromide bros (tio last longer)
what is the MOA of anticholinergic drugs
inhibit M receptors which leads to a lack of vasoconstriction
what are the side effects of anticholinergic drugs
- dry mouth
-cough - urinary retention
- blurred vision
- constipation
- tachycardia
what is the MOA of mast cell stabilizers
prevent the release of inflammatory mediator from mast cells
what is the clinical use for mast cell stabilizers
treatment for children with asthma
what are the side effects of mast cell stabilizers
- cough
- throat irritation
- rare allergic reactions
what is the clinical use for theophylline
chronic asthma
what are the side effects of theophylline
- insomnia
- gastric upset
- tachycardia
- seizures
what is the MOA of monoclonal antibodies
target and neutralize specific immune pathways
what is the clinical implication for monoclonal antibodies
severe allergic asthma
what are the side effects of monoclonal antibodies
- injection site reaction
- potential anaphylaxis
what are the classes of medications that can be used for COPD
- bronchodilators (beta agonists and anticholinergic)
- steroids
- phosphodiesterase 5 inhibitors
- O2 therapy
what is a phosphodiesterase 5 inhibitor drug
Roflumilast
what is the MOA of Roflumilast
decrease inflammation by inhibiting phosphodiesterase 5
what is the clinical use for Roflumilast
decrease risk for COPD exasterbation
what are the side effects of Roflumilast
- wt loss
- diarrhea
- nausea
- headache
- insominia
