sedatives, hypnotics, and anti anxiety medications Flashcards
Benzodiapines suffix
- azolam and -azepam
what is the MOA of benzodiapines
enhance the effect of GABA. hyperpolorizes the cell by allowing a greater influx of Cl- thus decreasing the excitability of the cell.
what are the effects of benzodiapines
1) decrease anxiety
2) induce sleep
3) antergrade amnesia
4) anticonvulsant effect
5) reduction of muscle tone and coordination
6) effects of respiration
7) effects on CVS
what are the side effects of benzodiapines
- hungover
- motor impairment
- confusion
- rebound insomnia when you stop taking
- potentates the CNS effect of ethanol
- tolerance
- dependance
what should you not take benzodiapines with
CNS depressants and alcohol
what is the antidote for benzodiapines
Flumazenil
what drugs are under the non benzodiazepines category
1) Z drugs
2) melatonin receptor agonists
3) orexin receptor antagonists
what is the prefix for Z drugs
Zol- , Zal- and EsZ-
what is the MOA of Z drugs
potent GABA effects but not in the same way as benzodiazepines
what are the side effects of Z drugs
- GI
- headache
- dizziness
has less of a rebound insomnia effect as benzodizepines
what is the suffix for melatonin receptor agonists
-melteon
what is the indication for Tasimelteon
non 24 hr sleep wake disorder
what is the side effect of Ramelteon
- headache
- dizziness
- somnolence
what is the side effect of Tasimelteon
- headache
- nightmares
- hepatotoxicity
what is the suffix for orexin receptor antagonists
-orexant
