Cardiac arrhythmias treatment

Question 1

MOA of class one antiarrythemia drugs

Answer 1

Na+ channel blocker. works on phase 0 depression

Question 2

what type of arrythmias do class 1 antiarrythemias treat

Answer 2

ventricular arrythmias

Question 3

what does 1A antiarrhythmic drugs cause

Answer 3

moderate phase 0 depression, prolonged repolarization, increased duration of AP, increase in refactory period

Question 4

class 1A antiarrhythmic drugs

Answer 4

1) quinidine
2) procainamide
3) disopyramide

Question 5

what does class 1B antiarrhythmics drugs do

Answer 5

weak phase 0 depression, shortened repolarization, decreased AP

Question 6

class 1B antiarrhythmic drugs

Answer 6

1) lidocaine
2) mexiletine

Question 7

Class 1C antiarrhythmic drugs do

Answer 7

strong phase 0 depression, little effect on repolarization, slows conduction in the heart

Question 8

Class 1C antiarrhythmic drugs

Answer 8

1) flecainide
2) propafenone

Question 9

Class 2 antiarrhythmic drugs

Answer 9

work on phase 4 of the cardiac action potential
beta blockers - blunt HR and force of contraction

Question 10

MOA of class 2 antiarrhythmic drugs -beta blockers

Answer 10

1) block B1 receptors in the heart
2) direct membrane stabilizing effects related to Na + channel blockade

Question 11

what arrhythmias do class 2 anti arrhythmic drugs treat

Answer 11

atrial tachycardia and ventricular arrhythmias

Question 12

class 3 antiarrhythmic drug MOA

Answer 12

k+ channel blockers- works at phase 3

Question 13

class 3 antiarrhythmic drugs

Answer 13

(-rone and -lide)
- amidoarone
-dronedarone
-ibtilide
- dofetilide

Question 14

class 4 antiarhrythmic drugs MOA

Answer 14

ca2+ channel blockers works at phase 2

Question 15

what arrythmias are class 4 drugs used to treat

Answer 15

atrial fibrillation by slowing the rate of the AV node

Question 16

class 4 antiarrthymia drugs

Answer 16

• verapamil
• diltiazem

Question 17

Adenosine

Answer 17

inhibits AV conduction

Question 18

Digoxin

Answer 18

reduces the conduction of the AV node - Aflutter Afib

Question 19

Atropine

Answer 19

blocks the vagal effects on the SA node - used to treat bradycardia

Question 20

Side effects of class 1A

Answer 20

can lead to torsades de pointes

Question 21

side effect of class 1B

Answer 21

drowsiness and seizures

Question 22

side effects of class 1C

Answer 22

visual disturbances and dizziness

Question 23

side effects of class 2 drugs

Answer 23

fatigue, bradycardia, and hypotension

Question 24

side effects of class 3 drugs

Answer 24

pulmonary toxicity, thyroid dysfunction, hepatotoxicity, corneal deposists

Question 25

side effects of class 4 drugs

Answer 25

constipation, hypotension, bradycardia