Cardiac arrhythmias treatment Flashcards
MOA of class one antiarrythemia drugs
Na+ channel blocker. works on phase 0 depression
what type of arrythmias do class 1 antiarrythemias treat
ventricular arrythmias
what does 1A antiarrhythmic drugs cause
moderate phase 0 depression, prolonged repolarization, increased duration of AP, increase in refactory period
class 1A antiarrhythmic drugs
1) quinidine
2) procainamide
3) disopyramide
what does class 1B antiarrhythmics drugs do
weak phase 0 depression, shortened repolarization, decreased AP
class 1B antiarrhythmic drugs
1) lidocaine
2) mexiletine
Class 1C antiarrhythmic drugs do
strong phase 0 depression, little effect on repolarization, slows conduction in the heart
Class 1C antiarrhythmic drugs
1) flecainide
2) propafenone
Class 2 antiarrhythmic drugs
work on phase 4 of the cardiac action potential
beta blockers - blunt HR and force of contraction
MOA of class 2 antiarrhythmic drugs -beta blockers
1) block B1 receptors in the heart
2) direct membrane stabilizing effects related to Na + channel blockade
what arrhythmias do class 2 anti arrhythmic drugs treat
atrial tachycardia and ventricular arrhythmias
class 3 antiarrhythmic drug MOA
k+ channel blockers- works at phase 3
class 3 antiarrhythmic drugs
(-rone and -lide)
- amidoarone
-dronedarone
-ibtilide
- dofetilide
class 4 antiarhrythmic drugs MOA
ca2+ channel blockers works at phase 2
what arrythmias are class 4 drugs used to treat
atrial fibrillation by slowing the rate of the AV node
