Drugs for RA Flashcards
1
Q
what are TNFa and IL1
A
pro-inflammatory mediators (cytokines) that increase the activity of osteoclasts.
1
Q
what are 2 ways in inhibit the autoimmune response in RA
A
1) decrease the production of cytokines (TNFa, IL, JAK)
2) decrease the cellular activation of monocytes (T and B cells)
2
Q
what are the 3 treatment options for RA
A
1)NSAIDS
2) Glucocorticoids
3) DMARDS
3
Q
Hydroxychlorquine
A
traditional DMARD
4
Q
Methotrexate
A
traditional DMARD
5
Q
Leflunomide
A
traditional DMARD
6
Q
Sulfasalzine
A
Traditional DMARD
7
Q
Ethanercept
A
TNFa blocker DMARD
8
Q
Inflizimab
A
TNFa blocker DMARD
9
Q
Adalimumab
A
TNFa blocker DMARD
10
Q
certolizumab
A
TNFa blocker DMARD
11
Q
golimumab
A
TNFa blocker DMARD
12
Q
Rituxiumab
A
non-TNFa DMARD (B cells)
13
Q
abatacept
A
non-TNFa DMARD (T-cell interaction)
14
Q
tocilizumab
A
non-TNFa DMARD ( IL-6)
