drugs for coagulation disorders Flashcards
what are the 3 different mechanisms to regulate coagulation
1) anticoagulants
2) antithrombotics
3) thrombolytics
anticoagulation drugs
1) warfin
2) heprin (unfractioned and LMWH)
3) direct thrombin inhibitor
4) factor xa inhibitor
what is the MOA of warfin
inhibit vitamin K dependent clotting factors
what are the side effects of warfin
bleeding, teratogenic and skin necrosis
what is the MOA of direct thrombin inhibitors
inhibit thrombin though factor 2a
what are the side effects of direct thrombin inhibitors
bleeding and GI issues
what are the suffixes for direct thrombin inhibitors
- tran
- troban
- rudin
what is the MOA for factor Xa inhibitors
inhibits Xa to prevent prothrombin from converting into thrombin
what are the side effects of factor Xa inhibitors
- bleeding
- pain in limbs
- headache
- dizziness
- abdominal pain
- elevated liver enzymes
what are the types of antithrombotics
1) Asprin
2) Ticagrelor and Prasugral
3) clopidgrel
4) Diapyridamole
what receptor does aspirin work on
COX 1
what receptor does Ticagrelor and prasugral work on
P2Y12
what receptor does clopidogrel work on
P2Y12
what receptor does dipyridamole work on
PDE
what are the side effects for antithrombotic drugs
- bleeding
- GI issues
- tinnitus
- Thrombotic Thrombocytopenic Purpura (TTP) = clopidgrel
