Drugs for alzheimers

Question 1

what are the pathological landmarks of alzheimers disease

Answer 1

• increase in tau-tangles
• increase in AB-plaques
• decrease in AcH
• increase glutamate
• increase cholesterol in neurons
• cerebrovascular changes

Question 2

what are the drugs that are used for mild to moderate alzheimers disease

Answer 2

cholinesterase inhibitors

Question 3

what are the 3 drugs that are cholinesterase inhibitors

Answer 3

1) Donepezil
2) Rivastigmine
3) Galantamine

Question 4

what is the the MOA of cholinesterase inhibitors

Answer 4

increase the amount of available AcH by blocking acetylcholinesterase enzyme

Question 5

what are the side effects of cholinesterase inhibitors

Answer 5

• N/V
• diarrhea
• dizziness
• blurred vision
• bradycardia
• skin reaction (galantamine)

Question 6

what are the drugs used for severe Alzheimer’s disease

Answer 6

Mematine and Donepezil

Question 7

what is the MOA of mematine

Answer 7

NMDA receptor antagonist and prevents Ca2+ excitoxicity

Question 8

what are the adverse effect of mematine

Answer 8

• headache
• confusion
• dizziness
• hallucinations
• conception

Question 9

what is Aducanumab used for

Answer 9

mild cognitive impairment or mild dementia stage of AD

Question 10

what is the MOA of Aducanumab

Answer 10

amyoid beta directed antibody