Sketchy: Trypanosoma brucei

Question 1

Cue:

• rolling hills outside the window

Answer 1

recurrent, undulating fevers

Question 2

After biting, the parasites move from the blood to the ______.

Answer 2

lymph nodes

Question 3

Because Trypanosoma brucei cause CNS infections, the treatments for them are ____.

Answer 3

highly toxic

Question 4

Cue:

• tea in teacup with fly inside on bedside table

Answer 4

tea and fly = tsetse fly vector

Question 5

Cue:

• trickle of blood from the fingertip next to a goat stuffed animal

Answer 5

trypomastigotes on blood smear

Question 6

What do Trypanosoma brucei cause?

Answer 6

sleeping sickness

Question 7

Cue:

• sleeping princess in a bed

Answer 7

sleeping sickness, coma

Question 8

Cue:

• single pink ribbon in her hair

Answer 8

motile with single flagella

Question 9

How are the Trypanosoma brucei transmitted?

Answer 9

painful bite of the Tsetse fly

Question 10

Cue:

• multicolored tents scattered across the grounds

Answer 10

variable surface glycoprotein coats undergoing constant antigenic variation

Question 11

Cue:

• pearl necklace and ruffled sleeves

Answer 11

cervical and axillary lymphadenopathy

Question 12

Cue:

• poster of Africa with Gambeza and Rhodesia pinned

Answer 12

Trypanosoma brucei Gambiense and Rhodesience

Question 13

Cue:

• Prince Bruce carrying a life-saving serum and a bar of soap

Answer 13

• life-saving serum = suramin - tx for peripheral blood (suramin treats serum)
• bar of soap = melarsoprol - tx for CNS infection