Sketchy: Naegleria fowleri

Question 1

How do you diagnose Naegleria fowleri?

Answer 1

lumbar puncture –> examine CSF under microscopy: (+) = swimming amoeba present

Question 2

Cue:

• water bottles

Answer 2

associated with nasal irrigation systems and contact lens solutions

Question 3

What kind of organism is Naegleria fowleri?

Answer 3

an amoeba

Question 4

Where is Naegleria fowleri found in nature?

Answer 4

in freshwater lakes (think water skiing, backpacking, hot springs)

Question 5

Which bacteria is classically associated with swimming in fresh water?

Answer 5

Leptospirosis

Question 6

In Naegleria fowleri, the trophozoite enters the CNS via cribiform plate, causing _______.

Answer 6

meningoencephalitis

Question 7

What does Naegleria fowleri cause?

Answer 7

meningoencephalitis

Question 8

What is the prognosis for Naegleria fowleri?

Answer 8

poor- it’s rapidly fatal

Question 9

Cue:

• man in the water with a neck brace and red turban

Answer 9

• neck brace = meningitis
• red turban = encephalitis

Question 10

Cue:

• dead man in the water with head smashed on a rock

Answer 10

rapidly fatal with poor prognosis

Question 11

Cue:

• man windsurfing

Answer 11

Affects pts involved in water sports

Question 12

Cue:

• amphibians all over the surviving man

Answer 12

amphoterecin is the tx (start ASAP)

Question 13

Cue:

• barrel riders in cribs going over Niagra Falls

Answer 13

• Niagra Falls = Naegleria fowleri
  
  • associated with fresh water
• barrel riders = usually fatal/high mortality rate
• cribs = trophozoite enters CNS via cribiform plate

Question 14

What is the tx for primary amoebic meningoencephalitis from Naegleria fowleri?

Answer 14

amphoterecin

Question 15

Cue:

• champagne with spinal needle-looking corkscrew

Answer 15

champagne tap (lumbar puncture w/o RBCs present) –> diagnose Naegleria fowleri with LP

Question 16

In Naegleria fowleri, the _____ enters the CNS via cribiform plate, causing meningoencephalitis.

Answer 16

trophozoite

Question 17

When Naegleria fowleri is the cause of meningitis and encephalitis, the disease is called ______.

Answer 17

primary amoebic meningoencephalitis

Question 18

In Naegleria fowleri, the trophozoite enters the ____ via the _______, causing meningoencephalitis.

Answer 18

CNS; cribiform plate