Sketchy: Poliovirus Flashcards
Name the 2 polio vaccines and how they’re administered.
- Salk = inactivated (killed) vaccine given parenterically thru an injection
- Sabin = live attenuated vaccine given orally
What is the downside to the Sabin (live) vaccine?
it can be shed in the feces –> transmitted to another person –> paralysis
Where are Peyer’s Patches found?
in the submucosa of the ileum
Cue:
- sun is up/daylight
positive sense RNA
What kind of Abs are formed from the Salk vaccine?
IgG only
After the lymph node, the virus spreads to the _____.
anterior horn of the lower motor neuron cell bodies
Polio causes ______ paralysis that is usually concentrated in the lower legs.
asymmetric
Cue:
- sign that says “Peyer’s Flamingos- Caution- Patches of Eggs- Breeding season 2-3 weeks”
- Peyer’s Patches = where virus replicates
- 2-3 weeks = incubation period
Where is polio still found?
in parts of Asia and Africa
Cue:
- kid wearing a space helmet
enteroviruses are #1 cause of viral meningitis in children
Where does poliovirus initially start replicating once ingested?
lymph tissue, like the tonsils and Peyer’s patches
How is polio transmitted?
fecal-oral
What causes death in polio pts?
respiratory insufficiency from ascending muscle paralysis
Cue:
- orange reeds with eggs embedded underneath
- orange reeds = villi of the intestines
- eggs = replication occurs in Peyer’s Patches
Cue:
- donation canister labeled “Savin’A Life”
- Savin’ = Sabin vaccine
- A = IgA response
- Life = live vaccine
Cue:
- yellow colored pool
stomach acid (acid stable virus)
What kind of Abs are formed from the Sabin vaccine?
both IgA and IgG
Poliovirus is a member of the _____ family.
picornavirus
Polio causes asymmetric paralysis that is usually concentrated in _______.
the lower legs
Cue:
- bird with very large horn
hornbill = anterior horn of the spinal cord is affected
Cue:
- baby flamingo next to the mom
pico baby counterpart = picornavirus
Cue:
- flamingo with bent leg, hunched over, with puff of air coming out of beak
- bent leg = asymmetric flaccid paralysis
- puff of air = respiratory insufficiency
What is the downside to the Salk (killed) vaccine?
it doesn’t cause an IgA response
What is the tx for polio?
none
Cue:
- emo teenager wearing a skull and crossbones tshirt
- sulking = Salk vaccine
- skull and crossbones = killed vaccine
Cue:
- Statue of David
naked virus
Cue:
- orange and yellow color scheme
RNA virus
What kind of virus is Poliovirus?
a naked, positive sense RNA virus
When does paralysis occur?
2-3 weeks following infection
