Sketchy: Poliovirus

Question 1

Name the 2 polio vaccines and how they’re administered.

Answer 1

1. Salk = inactivated (killed) vaccine given parenterically thru an injection
2. Sabin = live attenuated vaccine given orally

Question 2

What is the downside to the Sabin (live) vaccine?

Answer 2

it can be shed in the feces –> transmitted to another person –> paralysis

Question 3

Where are Peyer’s Patches found?

Answer 3

in the submucosa of the ileum

Question 4

Cue:

• sun is up/daylight

Answer 4

positive sense RNA

Question 5

What kind of Abs are formed from the Salk vaccine?

Answer 5

IgG only

Question 6

After the lymph node, the virus spreads to the _____.

Answer 6

anterior horn of the lower motor neuron cell bodies

Question 7

Polio causes ______ paralysis that is usually concentrated in the lower legs.

Answer 7

asymmetric

Question 8

Cue:

• sign that says “Peyer’s Flamingos- Caution- Patches of Eggs- Breeding season 2-3 weeks”

Answer 8

• Peyer’s Patches = where virus replicates
• 2-3 weeks = incubation period

Question 9

Where is polio still found?

Answer 9

in parts of Asia and Africa

Question 10

Cue:

• kid wearing a space helmet

Answer 10

enteroviruses are #1 cause of viral meningitis in children

Question 11

Where does poliovirus initially start replicating once ingested?

Answer 11

lymph tissue, like the tonsils and Peyer’s patches

Question 12

How is polio transmitted?

Answer 12

fecal-oral

Question 13

What causes death in polio pts?

Answer 13

respiratory insufficiency from ascending muscle paralysis

Question 14

Cue:

• orange reeds with eggs embedded underneath

Answer 14

• orange reeds = villi of the intestines
• eggs = replication occurs in Peyer’s Patches

Question 15

Cue:

• donation canister labeled “Savin’A Life”

Answer 15

• Savin’ = Sabin vaccine
• A = IgA response
• Life = live vaccine

Question 16

Cue:

• yellow colored pool

Answer 16

stomach acid (acid stable virus)

Question 17

What kind of Abs are formed from the Sabin vaccine?

Answer 17

both IgA and IgG

Question 18

Poliovirus is a member of the _____ family.

Answer 18

picornavirus

Question 19

Polio causes asymmetric paralysis that is usually concentrated in _______.

Answer 19

the lower legs

Question 20

Cue:

• bird with very large horn

Answer 20

hornbill = anterior horn of the spinal cord is affected

Question 21

Cue:

• baby flamingo next to the mom

Answer 21

pico baby counterpart = picornavirus

Question 22

Cue:

• flamingo with bent leg, hunched over, with puff of air coming out of beak

Answer 22

• bent leg = asymmetric flaccid paralysis
• puff of air = respiratory insufficiency

Question 23

What is the downside to the Salk (killed) vaccine?

Answer 23

it doesn’t cause an IgA response

Question 24

What is the tx for polio?

Answer 24

none

Question 25

Cue:

• emo teenager wearing a skull and crossbones tshirt

Answer 25

• sulking = Salk vaccine
• skull and crossbones = killed vaccine

Question 26

Cue:

• Statue of David

Answer 26

naked virus

Question 27

Cue:

• orange and yellow color scheme

Answer 27

RNA virus

Question 28

What kind of virus is Poliovirus?

Answer 28

a naked, positive sense RNA virus

Question 29

When does paralysis occur?

Answer 29

2-3 weeks following infection