Sketchy: Histoplasma Flashcards
1
Q
Cue:
- pinecones and frogs
A
- pinecone = -conazoles for local/mild
- frog = amphibian = Amphotericin B for systemic/disseminated
2
Q
How does Histo present in healthy pts?
A
asymptomatic/subclinical
3
Q
Cue:
- 2 pale cave pillars with red dots all over the fronts
A
- pillars = legs
- red dots = erythema nodosum
4
Q
Cue:
- a two-toned butterfly
A
dimorphic
5
Q
What happens when an immunocompromised pt gets histo?
A
hepatosplenomegaly with calcifications
6
Q
Cue:
- historian with a cane coughing
A
- cane = immunocompromised
- cough = respiratory transmission
7
Q
Cue:
- petroglyph of a cow with liver and spleen spots
A
hepatosplenomegaly
8
Q
Histo targets the _____, which includes a lot of macs, and these are highly concentrated in the liver and spleen –> calcifications in these organs.
A
reticulo-endothelial system
9
Q
Mold in the cold, yeast in the heat.
A
- mold = cold = soil
- yeast = heat = body (dimorphism)
10
Q
Where is Histoplasma capsulatum prevalent?
A
- inside caves
- farms
- the Midwest-Central US (Mississippi and Ohio River Valley)
11
Q
_______ is much smaller than an RBC, which is obvious because several fit inside one mac, and a mac is slightly larger than an RBC.
A
Histoplasma
12
Q
Cue:
- cage with a canary inside
A
cage = macrophage
13
Q
How is Histoplasma capsulatum diagnosed?
A
- macs filled with small, intracellular oval bodies –> stain with KOH prep culture (too long)
- rapid histoplasma urine or serum antigen test
14
Q
Cue:
- cracked cave walls with many stalactites growing on them, especially in the center, and a cactus in front
A
- cracks = lung lobes (3 on right, 2 on left)
- stalactites = lung calcifications
- in center = hilar region of lungs
- cactus = presentation resembles TB
15
Q
What does Histoplasma capsulatum cause?
A
histoplasmosis
