skeletal muscle relaxants Flashcards
succinylcholine
depolarizing agent
atracurium
nondepolarizing agnet
cisatracurium
nondepolarizing agnet
rocuronium
nondepolarizing agnet
vecuronium
nondepolarizing agnet
baclofen
centrally acting spasmolytic drugs
diazepam
centrally acting spasmolytic drugs
tizanidine
centrally acting spasmolytic drugs
dantrolene
direct acting muscle relaxant
these drugs compete with Ach for the binding site; they will also enter and block the ion channel at high doses
non-depolarizing relaxant drugs
these drugs reacts with the nicotinic receptor to open the ion channel and cause depolarization ( goes through phase one and phase two blocks)
depolarizing relaxant drugs
what is phase one block
flaccid paralysis results bc muscle fibers cannot repolarize
what is phase two block
due to prolonged exposure , repolarization occurs but it is desensitized
this specific drug is an agonists at the GABA receptors;
baclofen ( spasmolytic)
this specific drug is an alpha 2 agonist ; effective for migraines
tizanidine ( spasmolytic )
this specific drug reduces skeletal muscle strength by interfering with excitation- contraction coupling in the muscle fibers; prevents release of Ca by blocking the SR channel;
dantrolene ( direct acting muscle relaxant)