estrogens and androgens

Question 1

estradiol

Answer 1

estrogen

Question 2

estrone

Answer 2

estrogen

Question 3

estriol

Answer 3

estrogen

Question 4

raloxifene

Answer 4

selective estrogen receptor modulator

Question 5

tamoxifen

Answer 5

selective estrogen receptor modulator

Question 6

drospirenone

Answer 6

progestogen

Question 7

levonorgestrel

Answer 7

progestogen

Question 8

medroxyprogesterone

Answer 8

progestogen

Question 9

megestrol

Answer 9

progestogen

Question 10

norelgestromin

Answer 10

progestogen

Question 11

norethindrone

Answer 11

progestogen

Question 12

progesterone

Answer 12

progestogen

Question 13

mifepristone

Answer 13

antiprogestin

Question 14

testosterone

Answer 14

androgen

Question 15

bicalutamide

Answer 15

antiandrogen

Question 16

dutasteride

Answer 16

antiandrogen

Question 17

finasteride

Answer 17

antiandrogen

Question 18

flutamide

Answer 18

antiandrogen

Question 19

nilutamide

Answer 19

antiandrogen

Question 20

these drugs diffuse across cell membranes and bind to specific nuclear receptor proteins ; activated complex initiates RNA synthesis

Answer 20

steroid hormones

Question 21

these drug compete with estrogen for binding in breast tissue

Answer 21

SERMs ( selective estrogen receptor modulators )

Question 22

what is the most potent estrogen produced by the ovary; primary estrogen in premenopause

Answer 22

estradiol

Question 23

this is the primary circulating estrogen after menopause

Answer 23

estrone

Question 24

this is the estrogen produced by the placenta

Answer 24

estriol

Question 25

clinical uses for estrogens

Answer 25

contraception, hormone therapy, stimulate development in young women with hypogonadism, tx of premature menopause, and tx of osteoporosis

Question 26

AE of estrogens

Answer 26

uterine bleeding and endometrial cancer risk

Question 27

Which SERM drug decreases bone resorption and overall bone turnover

Answer 27

raloxifine

Question 28

clinical use of SERMS

Answer 28

palliative tx of metastatic breast cx , post mastectomy, tx of osteoporosis , infertility

Question 29

AE of SERMS

Answer 29

hot flashes and nausea, many drug interactions, increased risk of thrombosis

Question 30

what is the natural progestogen

Answer 30

progesterone

Question 31

this hormone is produced in response to LH in males and females

Answer 31

progesterone

Question 32

clinical use of progestogens

Answer 32

tx of hormonal def. , contraception, dysfunctional uterine bleeding,

Question 33

AE of progestogens

Answer 33

HA, depression, weight gain, acne

Question 34

which drug if admin. early in pregnancy can result in abortion of the fetus

Answer 34

mifepristone

Question 35

which drug is used as an emergency contraceptive

Answer 35

levonorgestrel

Question 36

AE of contraceptives

Answer 36

fluid retention, HA, nausea, vomiting, etc.

Question 37

what is the most important androgen in humans

Answer 37

testosterone

Question 38

this drug binds to a specific nuclear receptor ; hormone receptor complex binds to DNA and stimulates synthesis of specific RNAs and proteins

Answer 38

testosterone

Question 39

clinical uses for androgens

Answer 39

androgenic effects, anabolic effects, endometriosis AE= masculinization, acne, growth of facial hair ( Females) and in males impotence, female cosmetic changes, stimulates growth of prostate

Question 40

these drugs block the synthesis of androgens and their receptors

Answer 40

antiandrogens

Question 41

which drugs are used to tx BPH

Answer 41

finasteride and dutasteride

Question 42

which drug is used to tx prostatic carcinoma

Answer 42

flutamide

Question 43

which drugs are effective oral tx for prostate cancer

Answer 43

Bicalutamide and nilutamide