drugs targeting central opiate systems

Question 1

activation of these opioid receptor channels leads to opening of K channels

Answer 1

Mu/Delta

Question 2

activation of these drug receptors leads to inhibition of adenylyl cyclase and a decrease in the concentration of cAMP

Answer 2

opioids

Question 3

these drugs are used in the reversal of opiate overdose;

Answer 3

opiate receptor antagonist

Question 4

fentanyl

Answer 4

opioid agonist

Question 5

meperidine

Answer 5

opioid agonist

Question 6

hydromorphone

Answer 6

opioid agonist

Question 7

these drugs show agonist activity in drug naiive pts; they show antagonist activity in pts with opioid dependence

Answer 7

mixed agonist antagonist

Question 8

methadone

Answer 8

opioid agonist

Question 9

these drugs commonly used for pain control and as an anesthetic

Answer 9

morphine and fentanyl

Question 10

hydrocodone

Answer 10

partial opioid agonist

Question 11

Percodan ( oxycodone + acetaminophen)

Answer 11

common combo drug

Question 12

morphine

Answer 12

opioid agonist

Question 13

this drug selectively targets GI opiate receptors which is used to tx diarrhea

Answer 13

loperamide

Question 14

lortab ( hydrocone + acetaminophen

Answer 14

common combination drug

Question 15

buprenorphine

Answer 15

mixed agonist- antagonist

Question 16

activation of these opioid receptors leads to less Ca influx into the pre synaptic nerve terminal

Answer 16

Kappa

Question 17

oxycodone

Answer 17

opioid agonist

Question 18

nalbuphine

Answer 18

mixed agonist- antagonist

Question 19

Tylenol ( codeine + acetaminophen )

Answer 19

common combo drug

Question 20

this drug binds to opioid receptor and weakly inhibits reuptake of NE and serotonin;

Answer 20

tramadol ( opioid receptor agonists)

Question 21

tramadol

Answer 21

mixed mechanism

Question 22

oxymorphone

Answer 22

opioid agonist

Question 23

naloxone

Answer 23

opioid antagonists

Question 24

Percocet ( oxycodone + acetaminophen)

Answer 24

common combo drug

Question 25

heroin

Answer 25

opioid agonist

Question 26

codeine

Answer 26

partial opioid agonist

Question 27

levorphanol

Answer 27

opioid agonist